The Alfredo A. Sadun Neuro-Ophthalmology Collection: A Professor of Ophthalmology and Neurological Surgery at the USC Keck School of Medicine, Dr. Sadun with a team of researchers at the Doheny Eye Institute pioneered research in optic nerve dysfunction in patients with Alzheimer's disease. Contains his "100 best lectures." Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor Ophthalmology & Neurological Surgery, Doheny Eye Institute, Keck School of Medicine at USC.
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Anatomy and Physiology of Vision: The Visual Pathways | Introduction to neuro-ophthalmology, covering the optic nerve, the afferent visual system (eye to brain), the pupil (Afferent-Efferent Reflex), and the efferent visual system (eye movements). Anatomy: Optic nerve; Optic disc; Retina; Retinal ganglion cells; Optic chiasm; Visual cortex. Disease/Diagn... | Text |
| 2 |
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Field Investigation of a Giant Pedigree of LHON in Rural Brazil | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness, | Text |
| 3 |
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Leber's Hereditary Optic Neuropathy (LHON): New Rules of Engagement | Slide presentation with several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness. | Text |
| 4 |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree From Brazil | Four slides showing optic disc with LHON. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness. | Text |
| 5 |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree in Brazil | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images of optic nerve and optic disk with LHON, Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres... | Text |
| 6 |
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Mitochondria and the RGC | Discussion of various forms of mitrochondrial optic neuropathies and how to distinguish from toxic optic neuropathies, with examples from Cuba and Brazil. Presenting Symptom: Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia. Anatomy: Optic nerve; Optic disc; Retinal ganglion cells; Reactive oxyge... | Text |
| 7 |
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Neuroprotection = Apoptosis of Retinal Ganglion Cells | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Presenting Symptom: Blindness; Ischemia; Retinal detachment. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunod... | Text |
| 8 |
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Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for Apoptosis | Presentation at Harvard in 2006, focussing on Leber's Heriditary Optic Neuropathy; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic nerve diseases; Optic Atrophy, Hereditary, Leber. Presenting Symptom:... | Text |
| 9 |
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Leber's Hereditary Optic Neuropathy: New Lessons From a Giant Pedigree in Brazil | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres... | Text |
| 10 |
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Apoptosis in LHON: An ROS Explanation | A slide presentation describing apoptosis in LHON; includes several images of optic nerve and optic disk. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Text |
| 11 |
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Induction of Apoptosis by Mitochondrial Impairment in LHON and Related Diseases | Slide presentation includes six pairs of microscopic slides showing LHON and control examples of optic nerve. Anatomy: Optic nerve. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Text |
| 12 |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree in Brazil | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindnes... | Text |
| 13 |
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Subclinical Visual Abnormalities in Carriers With 11778 LHON from a 300 Member Brazilian Pedigree | Report of a multi-year international field investigation to rural Brazil to study a cluster of LHON, including its genetic roots. Presenting Symptom: Scotoma; Telangiectasis; Blindness. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Pathology: Slides showing LHON ... | Text |
| 14 |
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Mitochondrial Optic Neuropathies (MON) | Combination of two presentations on optic nerve diseases, covering the cases in Cuba and Brazil. Titles: Cuban epidemic of optic neuopathy: even zealots must eat, or, Conversations with Castro and Leber's hereditary optic neuropathy: a very large new pedigree in Brazil; includes several images of ... | Text |
| 15 |
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Beyond the Margulis Hypothesis: The Time Bomb Within Us | Presented at Harvard, 2005; includes several images of optic disc with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Dyschromatopsia; Scotoma. | Text |
| 16 |
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Beyond the Margulis Hypothesis: The Time Bomb Within Us | Presented at 36th Annual Doheny Days, 2005. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Text |
| 17 |
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Acute Retrobulbar Optical Neuropathy | PPT covering acute retrobulbar optic neuropathy, including ischemic, inflammatory, anterior ischemic optic neuropathy (AION) and non-arteritic anterior ischemic optic neuropathy (NAION); includes brainscan images for optic neuritis and multiple sclerosis; optic disk with LHON and PION. Anatomy: Opt... | Text |
| 18 |
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Leber's Hereditary Optic Neuropathy (LHON) in Brazil: Opportunities | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic roots. Presented at Allergan, 2006. Includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Myelin sheath; Optic Disk. Disease/Diagnosis: Optic Atrophy, H... | Text |
| 19 |
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A Neuro-Ophthalmologist's View of RGC Apoptosis and Neuroprotection | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma. Presen... | Text |
| 20 |
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Atypical Optic Neuropathies | A discussion of atypical optic neuropathies. Anatomy: Optic nerve; Optic disc. Pathology: Slides showing LHON. Disease/Diagnosis: Optic neuropathy, Ischemic; Optic atrophy, Hereditary, Leber; Toxic optic neuropathy. Presenting Symptom: Optic neuritis; Eye hemorrhage; Retinal vasculitis; Dyschromatop... | Text |
| 21 |
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Extremely High Resolution Magnetic Resonance Imaging of the Human Optic Nerve Head | MRI imagery of optic nerves demonstrates ability to identify cases of Leber's Hereditary Optic Neuropathy (LHON); includes MRI images of optic nerves. Anatomy: Optic nerve. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Text |
| 22 |
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Leber's Hereditary Optic Neuropathy: New Insights? | Several microscopic images of optic nerve with LHON. Anatomy: Optic nerve. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Scotoma; Dyschromatopsia. | Text |
| 23 |
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Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for Apoptosis | Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Toxic optic neuropathy. Presenting Symptom: Scotoma; Dyschromatopsia. | Text |
| 24 |
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The Diagnostic Workup in Patients With Optic Neuropathies | Slideshow presentation with images of optic disc with edema and optic atrophy. Presenting Symptom: Telangiectasis; Dyschromatopsia; Scotoma. Anatomy: Optic nerve; Optic disc; Phosphopyruvate Hydratase; Enolase. Disease/Diagnosis: Optic neuritis; Macular edema; Optic neuropathy, Ischemic; Optic atrop... | Text |
| 25 |
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Jonathan D. Wirtschafter, MD, FACS, Frank E. Burch Professor of Ophthalmology | Overview of the life of Jonathan D. Wirtschafter on the occasion of the first annual Wirtschafter Lectureship, in August of 2003. Sadun gave the lecture, recapping an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images o... | Text |