NOVEL - Alfredo A. Sadun Collection
 
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1 Anatomy and Physiology of Vision: The Visual PathwaysIntroduction to neuro-ophthalmology, covering the optic nerve, the afferent visual system (eye to brain), the pupil (Afferent-Efferent Reflex), and the efferent visual system (eye movements). Anatomy: Optic nerve; Optic disc; Retina; Retinal ganglion cells; Optic chiasm; Visual cortex. Disease/Diagn...Text
2 Apoptosis of Retinal Ganglion CellsPresented at a conference on neuroprotection at Sedona, Arizona, 2002; includes several microscopic images demonstrating cell death. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma.Text
3 Compressive Optic Neuropathies PotpourriAn overview of compressive optic neuropathies, including symptoms, varieties, testing, and treatments; slide presentation includes several neuroimaging scans. Anatomy: Optic nerve. Disease/Diagnosis: Compression of optic nerve. Treatment: MifepristoneText
4 Distinguishing an Optic Neuropathy from a MaculopathyPPT describing a case of optic neuropathy. Covers signs and symptoms, and various laboratory tests. Describes 10 signes of disc edema. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; Afferent pupillar...Text
5 Distinguishing Optic Nerve vs. Retinal LesionsPPT describing methods of distinguishing optic nerve verses retinal lesions. Describes a pateint case. Discussed signs, symtpoms and diagnostic tests. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; A...Text
6 Engineering the Visual SystemPhysiological basis of vision, covering perimetry, retinal ganglion cell types, and retinal pathways. Anatomy: Optic nerve; Retina.Text
7 Field Investigation of a Giant Pedigree of LHON in Rural BrazilReport of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness,Text
8 Leber's Hereditary Optic Neuropathy (LHON): New Rules of EngagementSlide presentation with several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness.Text
9 Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree From BrazilFour slides showing optic disc with LHON. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness.Text
10 Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree in BrazilReport of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images of optic nerve and optic disk with LHON, Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres...Text
11 Management Approach to Isolated Ocular Motor Nerve PalsiesAnatomy: Optic nerve; Oculomotor nerve; Trochlear nerve; Abducens nerve; Pupil. Disease/Diagnosis: Oculomotor nerve diseases; Trochlear nerve diseases; Oculomotor nerve paralysis; Fourth cranial nerve palsy; Abducens nerve diseases; Gradenigo's syndrome; Ophthalmoplegia; Temporal Arteritis; Nerve co...Text
12 Mitochondria and the RGCDiscussion of various forms of mitrochondrial optic neuropathies and how to distinguish from toxic optic neuropathies, with examples from Cuba and Brazil. Presenting Symptom: Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia. Anatomy: Optic nerve; Optic disc; Retinal ganglion cells; Reactive oxyge...Text
13 Neuro-Surgical Approaches to the OrbitDiscusses specifics of various approaches to surgical treatment of lesions, including transcranial and transfrontal orbitotomies; neuroimagery scans from before and after operation for meningioma. Presenting Symptom: Proptosis. Anatomy: Orbit; Optic nerve sheath. Disease/Diagnosis: Meningioma; Heman...Text
14 Neuroprotection = Apoptosis of Retinal Ganglion CellsSlide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Presenting Symptom: Blindness; Ischemia; Retinal detachment. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunod...Text
15 Office Techniques for Detecting Optic Nerve DiseaseDemonstration of brightness sense testing and of computer-generated graphics for Amsler grid testing. Presenting Symptom: Scotoma; Metamorphopsia. Anatomy: Optic nerve; Retina; Macula lutea. Disease/Diagnosis: Glaucoma; Optic neuritis; Macular degeneration.Text
16 Optic Nerve RegenerationA slide presentation with three sets of 3 views increasing magnification. Anatomy: Optic nerve; Retina. Disease/Diagnosis: Optic neuropathy, Ischemic; Retrograde degeneration; Necrosis. Treatment: Cerestat; Aptiganel; Memantine; Riluzole.Text
17 Optic Neuritis Treatment TrialsAnatomy: Optic nerve. Disease/Diagnosis: Optic neuritis; Multiple sclerosis. Treatment: Methylprednisolone; Prednisone; Solumedrol.Text
18 Testing the Functional PatientDiscusses testing to distinguish organic ailments from psychosomatic or willful simulation of symptoms. Anatomy: Optic nerve; Retina. Disease/Diagnosis: Optic nerve diseases; Retinal degeneration; HysteriaText
19 Viagra and Vision Loss: Does Sex Make You Blind?At a formal debate during a meeting in Canada in Sept. 2006, Sadun was assigned the role of arguing the case FOR a connection between taking phosphodiesterase 5 (PDE5) inhibitors and developing anterior ischemic optic neuropathy. Presenting Symptom: Hypotension. Anatomy: Optic nerve; Optic disc; Cyc...Text
20 Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for ApoptosisPresentation at Harvard in 2006, focussing on Leber's Heriditary Optic Neuropathy; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic nerve diseases; Optic Atrophy, Hereditary, Leber. Presenting Symptom:...Text
21 An Epidemic of Blindness in Cuba: Lessons on Nutrition and MitochondriaPresented at Stanford in April 2007, recapping the 1990s expedition to Cuba to investigate causes of blindness epidemic. Anatomy: Optic nerve. Disease/Diagnosis: Optic nerve diseases; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Ambliopia; Ataxia; Paresthesia; Hyporeflexia.Text
22 Optic Nerve Sheath Decompression in the Management of Optic NeuropathiesA slide presentation with several images of optic disc, normal and with edema. Anatomy: Optic nerve; Optic disc. Disease/Diagnosis: Optic neuropathy, Ischemic; Pseudotumor cerebri; Papilledema. Treatment: Decompression, Surgical.Text
23 Leber's Hereditary Optic Neuropathy: New Lessons From a Giant Pedigree in BrazilReport of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres...Text
24 Apoptosis in LHON: An ROS ExplanationA slide presentation describing apoptosis in LHON; includes several images of optic nerve and optic disk. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber.Text
25 The Diagnostic Workup in Patients With Optic Neuropathies (Metodo diagnostico)Slideshow presentation with images of optic disc with edema and "Positive temporal artery biopsy". Presenting Symptom: Hyperopia; Metamorphopsia. Anatomy: Optic nerve; Macula Lutea; Optic disc. Disease/Diagnosis: Optic neuritis; Macular edema; Optic neuropathy, Ischemic.Text
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