: Localization of ED3-positive subpopulation of macrophages in spleen (rat)

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Title : Localization of ED3-positive subpopulation of macrophages in spleen (rat)
Creator Poels, Lambert G.
Contributor Lambert G. Poels, PhD, UMC St Radboud Nijmegen; Paul H. K. Jap, PhD, UMC St Radboud Nijmegen
Date 2010-06-11
Subject metallophilic macrophages; ED3 antibody; marginal zone
Description Stain: Immunohistochemistry of Vector red staining using the antibody ED3. The survey in (A) shows that the ED3-positive macrophages are found as a ring in the marginal zone border, as well as spread in the red pulp area (2). The cells are sometimes referred as marginal metallophilic macrophages. The PALS zone (1) is mostly devoid of this cell type. The cells have long slender processes as shown in (B). ED3 stains the CD169 antigen (Sn) and is involved in the binding of neoglycoproteins. In the spleen the marginal zone macrophages and a subpopulation of the marginal metallophils possess glycosylbinding receptors.
Subtype Image
Format image/jpeg
Collection Poja Histology Collection - Lymphatic Tissues and Organs Subset
ARK ark:/87278/s6qc35qf
Setname ehsl_heal
Date Created 2012-12-11
Date Modified 2012-12-11
ID 890908
Reference URL https://collections.lib.utah.edu/ark:/87278/s6qc35qf