Title |
The effect of cyclophosphamide treatment on the B and T cells in spleen (rat) |
Creator |
Poels, Lambert G. |
Contributor |
Lambert G. Poels, PhD, UMC St Radboud Nijmegen; Paul H. K. Jap, PhD, UMC St Radboud Nijmegen |
Date |
2010-06-11 |
Subject |
CD3 lymphocytes; CD8 lymphocytes; B lymphocytes; cyclophosphamide |
Description |
Stain: Immunoperoxidase staining using diaminobenzidin (DAB)/ hematoxylin counterstained on frozen section with antibodies to B cells (Mark 1), CD3 and CD8 T cells. (A): B cells in the follicles, germinal centres (2) and corona are stained positive brown, while the PALS area (1) is negative (blue). (B): About half of the lymphocytes in the PALS area (1) are stained brown positively. The B cell areas (2) are negative (blue). (C): About half of the lymphocytes in the PALS area (1) are stained positively, while the B cell area (2) remains unstained. Both B cells and T cells are reduced 4-8 days after the cyclophosphamide treatment. Cyclophosphamide causes temporarily severe immunosupression. |
Subtype |
Image |
Format |
image/jpeg |
Rights |
https://rightsstatements.org/page/CNE/1.0/ |
Collection |
Poja Histology Collection - Lymphatic Tissues and Organs Subset |
ARK |
ark:/87278/s6g19336 |
Setname |
ehsl_heal |
ID |
890879 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6g19336 |