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Show 295 Prognosis of Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Chloe Li 1, Jeffrey Odel 1, Meital Ben-Dov 2 1 Columbia University, 2 Columbia Medical Center Introduction: This study aims to identify patients with NAION who experienced a decline in vision over time and investigate potential risk factors associated with a poor prognosis. Methods: A retrospective chart review was conducted for NAION patients diagnosed between June 1, 2022, and June 10, 2023. Included adults (≥18 years) with at least two clinic visits, acute painless vision loss in one eye, and optic disc swelling. Patients with high inflammatory markers or positive temporal artery biopsy were excluded. Epidemiological, clinical, and ancillary data, including visual field testing, optical coherence tomography, and fundus images, were reviewed. Patients were assessed within two weeks of symptom onset and followed up for up to three months from presentation. Results: Included 9 patients (4 males). Among them, 5 patients (55.5%) had worsening vision (unstable group, UG) with mean age of 68, while the stable group (SG) mean of 66. Four UG and 2 SG patients had prior NAION, with no significant differences in comorbidities. UG patients were seen at a mean of 9.5 days after presentation (9 days for SG patients), with UG follow-ups at 18.75 days (SG at 21.2 days). UG's mean visual acuity at follow-up was 20/125, while SG had 20/30. Visual field testing MD showed UG at -8.1 (acute) and -18.6 (follow-up) and SG at -8.96 (acute) and -8.17 (follow-up). IOP was slightly higher in UG (15.6/16.4 mmHg, acute/follow-up) than SG (13.3/13.25 mmHg, acute/follow-up). Fundus revealed prolonged swelling in UG and earlier pallor development in SG, with a smaller c/d ratio in UG. Conclusions: We identified 2 groups: stable and unstable vision loss. Risk factors for unstability encompass prior fellow eye NAION and elevated IOP. The UG displayed lower color plate scores, smaller cups, and persistent edema. Studying this subgroup can yield valuable insights into the factors underlying vision deterioration in specific NAION subgroups. References: None provided. Keywords: Optic neuropathy, Vascular disorders Financial Disclosures: The authors had no disclosures. Grant Support: None. Contact Information: Meital Ben Dov, mb4955@cumc.columbia.edu 2024 Annual Meeting Syllabus | 453 |
