Demographic and Epidemiological Profile of Optic Neuritis in Colombia: A Retrospective Study Using Data from the Comprehensive Information System for Social Protection

Optic neuritis (ON) comprises a group of entities leading to the demyelination of the optic nerve. The prevalence of ON has not been studied in Latin-American countries. We aim to describe the demographic characteristics of ON in Colombia from 2015 to 2021.

273 Demographic And Epidemiological Profile Of Optic Neuritis In Colombia: A Retrospective Study Using Data From The Comprehensive Information System For Social Protection. Alvaro Mejia Vergara 1, Bryce Buchowicz 2 1 Univeristy of Florida, 2 University of Florida Introduction: Optic neuritis (ON) comprises a group of entities leading to the demyelination of the optic nerve. The prevalence of ON has not been studied in Latin-American countries. We aim to describe the demographic characteristics of ON in Colombia from 2015 to 2021. Methods: This is a descriptive cross-sectional study collecting data from individual health service records within the Integrated Social Protection Information System (SISPRO) of the Colombian health system, from January 1, 2015, to December 31, 2021. ON data was classified in SISPRO according to the International Statistical Classification of Diseases and Related Health Problems (ICD-10). We conducted descriptive analyses to delineate geographical patterns, age, and gender as well as estimate the prevalence of ON in Colombia. Results: 22,525 ON cases were identified. 6,336 (28.12%) had a diagnosis of neuromyelitis optica spectrum disorder (NMOSD) and 16,189 (71.88%) with a diagnosis of non-NMOSD divided into multiple sclerosis (MS) and non-NMOD/non-MS cases. The incidence of non-NMOSD and NMOSD was calculated at 7.29 and 2.05 cases per 100,000 individuals, respectively. 78.5% of NMOSD patients were female, with a higher prevalence in Risaralda, Sucre, and Bogotá. For MS associated ON, 64.1% of patients were female, with a higher prevalence in Antioquia, Sucre, and Tolima. For non-NMOSD/non-MS cases, 55.3% of cases were female, with a higher prevalence in Bogotá. Conclusions: This is the first epidemiological study of ON conducted in Colombia. Diagnosis of MS was more frequently made in regions with a larger Caucasian population, while NMOSD and non-NMOSD/non-MS diagnosis were more prevalent in more racially diverse states. Other types of specific antibodies are of limited availability in Colombia. References: None provided. Keywords: Optic neuritis Financial Disclosures: The authors had no disclosures. Grant Support: None Contact Information: Alvaro Mejia Vergara, MD, [e-mail] 2024 Annual Meeting Syllabus | 433