| Identifier |
20240307_nanos_pediatric1_03 |
| Title |
Is It Iatrogenic? Monitoring of Ophthalmic Complications: Radiation, MEK inhibitors, and Chemotherapy |
| Creator |
Marc Dinken, MD |
| Affiliation |
Weill Cornell Medical College, New York, NY |
| Subject |
Pediatric Oncology; Radiation Optic Neuropathy; MEK Inhibitors; BRAF Inhibitors; Immunotherapy |
| Description |
This lecture will review some of the potential neuro-ophthalmic complications of various anti-cancer therapies in children. Through a case-based approach, we will discuss the risks of radiation therapy including radiation optic neuropathy and ocular neuromyotonia, retinopathies related to the mitogenactivated protein kinase kinase (MEK) inhibitors and the cytarabine induced intracranial hypertension syndrome. Theoretical mechanisms will be discussed as will the diagnostic challenge of differentiating cancer-associated symptoms from those that are iatrogenic. |
| Date |
2024-03 |
| References |
1. Kim IK, Lane AM, Egan KM, Munzenrider J, Gragoudas ES. Natural history of radiation papillopathy after proton beam irradiation of parapapillary melanoma. Ophthalmology. 2010 Aug;117(8):1617-22. doi: 10.1016/j.ophtha.2009.12.015. Epub 2010 Apr 3. PMID: 20363507. 2. Finger PT, Chin KJ, Tena LB. A five-year study of sloted eye plaque radiation therapy for choroidal melanoma: near, touching, or surrounding the optic nerve. Ophthalmology. 2012 Feb;119(2):415-22. doi: 10.1016/j.ophtha.2011.08.017. Epub 2011 Nov 30. PMID: 22133796. 3. Archer EL, Liao EA, Trobe JD. Radiation-Induced Optic Neuropathy: Clinical and Imaging Profile of Twelve Patients. J Neuroophthalmol. 2019 Jun;39(2):170-180 4. Borruat FX, Schatz NJ, Glaser JS, Feun LG, Matos L. Visual recovery from radiation-induced optic neuropathy. The role of hyperbaric oxygen therapy. J Clin Neuroophthalmol 1993;13:98-10 5. Finger PT, Chin KJ. Anvascular endothelial growth factor bevacizumab for radiation optic neuropathy: secondary to plaque radiotherapy. Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):789-98. doi: 10.1016/j.ijrobp.2010.11.075. Epub 2011 Jan 27. PMID: 21277107. |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2024 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2024: Pediatric Neuro-Ophthalmology: Pediatric Brain Tumors: In Childhood and Beyond |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2024. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6s8jkcx |
| Setname |
ehsl_novel_nam |
| ID |
2589425 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6s8jkcx |
