| Identifier |
20240304_nanos_global1_05 |
| Title |
Optic Neuritis Treatment Trial (ONTT) |
| Creator |
Neil R. Miller, MD & Gordon Plant, MBBS |
| Affiliation |
Johns Hopkins University School of Medicine, Baltimore, Maryland |
| Subject |
Optic Neuritis; Visual Prognosis; Contrast Sensitivity; Steroid Treatment; Multiple Sclerosis |
| Description |
In 1949, Hench et al. (1) described the beneficial effects of systemic corticosteroids in the treatment of rheumatoid arthritis. Following this report, physicians began to consider other disorders, including acute optic neuritis, that might respond to similar treatment or to treatment with adrenocorticotrophic hormone (ACTH). The first systematic attempt to address this issue was a double-blind, prospective study; of the treatment of 50 patients with acute retrobulbar neuritis with either ACTH or placebo (2,3). The study showed that the group treated with ACTH recovered vision faster than the group give placebo, but at 1 year, the mean visual acuities in the two groups were not significantly different from each other. |
| Date |
2024-03 |
| References |
1. Hench PS, Kendall EC, Slocumb CH, Polley HF. The effect of a hormone of the adrenal cortex (17 hydroxy 11 dehydrocorticosterone: compound E) and of pituitary adrenocorticotrophic hormone on rheumatoid arthritis. Proc Staff Meet Mayo Clin. 1949; 24:181-1972 2. Rawson MD, Liversedge LA, Goldfarb G. Treatment of acute retrobulbar neuritis with corticotrophin. Lancet. 1966; 2:1044-1046 3. Rawson MD, Liversedge LA. Treatment of retrobulbar neuritis with corticotrophin. Lancet.1969; 2:222. 4. Rose AS, Kuzma JW, Kurtzke JF, Namerow NS, Sibley WA, Tourtellotte WW. Cooperative study in the evaluation of therapy in multiple sclerosis: ACTH vs. placebo final report. Neurology. 1970; 20:1-59. 5. Bowden AN, Bowden PMA, Friedmann AI, Perkin GD, Rose FC. A trial of corticotrophin gelatin injection in acute optic neuritis. J Neurol Neurosurg Psychiatry. 1974; 37:869-873. |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2024 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2024: Global Perspectives: Lost in translation? How major neuro-ophthalmic trials are applied locally (US/Canada) versus internationally |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2024. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s611s9t3 |
| Setname |
ehsl_novel_nam |
| ID |
2589379 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s611s9t3 |
