Title |
Should Aquaporin-4 Antibody Test Be Performed in all Patients With Isolated Optic Neuritis? |
Creator |
Rosalynn G. Siantar; Farah N. I. Ibrahim; Hla M. Htoon; Sharon L. C. Tow; Kong Yong Goh; Jing Liang Loo; Su Ann Lim; Dan Milea; Melissa C. H. Tien; Zhiyong Chen; Tianrong Yeo; Josiah Y. H. Chai; Shweta Singhal; Chee Fang Chin; Kevin Tan |
Affiliation |
National Healthcare Group Eye Institute (RGS, SAL, MT, CFC), Tan Tock Seng Hospital, Singapore ; Department of Neuro-Ophthalmology (FI, ST, JLL, DM, SS), Singapore National Eye Centre, Singapore ; Data Science Unit (HMH), Singapore Eye Research Institute, Singapore ; Mount Elizabeth Novena Hospital (KYG), Singapore ; Department of Neurology (ZC, TY, JC, KT), National Neuroscience Institute, Singapore ; and Duke-NUS Medical School (KT), Singapore |
Abstract |
Optic neuritis (ON) may be the initial manifestation of neuromyelitis optica spectrum disorder (NMOSD). Aquaporin-4 antibody (AQP4 Ab) is used to diagnose NMOSD. This has implications on prognosis and is important for optimal management. We aim to evaluate if clinical features can distinguish AQP4 Ab seropositive and seronegative ON patients. |
Subject |
Aquaporin 4; Autoantibodies; Neuromyelitis Optica; Optic Neuritis; Visual Acuity; Young Adult |
Date |
2022-12 |
Date Digital |
2022-12 |
References |
1. Bennett JL. Optic neuritis. Continuum (Minneap Minn). 2019;25:1236-1264. 2. Hor JY, Asgari N, Nakashima I, Broadley SA, Leite MI, Kissani N, Jacob A, Marignier R, Weinshenker BG, Paul F, Pittock SJ, Palace J, Wingerchuk DM, Behne JM, Yeaman MR, Fujihara K. Epidemiology of neuromyelitis optica spectrum disorder and its prevalence and incidence worldwide. Front Neurol. 2020;11:501. 3. Chen JJ, Pittock SJ, Flanagan EP, Lennon VA, Bhatti MT. Optic neuritis in the era of biomarkers. Surv Ophthalmol. 2020;65:12-17. 4. Jarius S, Frederikson J, Waters P, Paul F, Akman-Demir G, Marignier R, Franciotta D, Ruprecht K, Kuenz B, Rommer P, Kristoferitsch W, Wildemann B, Vincent A. Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis. J Neurol Sci. 2010;298:158-162. 5. Petzold A, Pittock S, Lennon V, Maggiore C, Weinshenker BG, Plant GT. Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune mediated optic neuritis. J Neurol Neurosurg Psychiatry. 2010;81:109-111. |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Publication Type |
Journal Article |
Source |
Journal of Neuro-Ophthalmology, December 2022, Volume 42, Issue 4 |
Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
Publisher |
Lippincott, Williams & Wilkins |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
© North American Neuro-Ophthalmology Society |
ARK |
ark:/87278/s64tgtmz |
Setname |
ehsl_novel_jno |
ID |
2392993 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s64tgtmz |