| Identifier |
20230316_nanos_pathway1_04 |
| Title |
Transynaptic Retrograde Degeneration |
| Creator |
Jonathan C. Horton, MD, PhD |
| Affiliation |
UCSF, San Francisco, California |
| Subject |
Ganglion Cell Complex; Homonymous Hemianopia; Optical Coherence Tomography; Optic Atrophy; Inner Nuclear Layer |
| Description |
More than half a century ago, the phenomenon of transneuronal retrograde degeneration was shown convincingly at two levels of the monkey visual system: 1) within the inner nuclear layer of the retina, where cysts form after ganglion cell axon transection and 2) in the retinal ganglion cell layer, where neurons are lost after occipital lobe removal. |
| Date |
2023-03 |
| References |
1. Van Buren JM. Trans-synaptic retrograde degeneration in the visual system of primates. J Neurol Neurosurg Psychiatry 1963;26:402-9. 2. Mehta JS, Plant GT. Optical coherence tomography (OCT) findings in congenital/long-standing homonymous hemianopia. Am J Ophthalmol 2005;140(4):727-9. 3. Jindahra P, Petrie A, Plant GT. Retrograde trans-synaptic retinal ganglion cell loss identified by optical coherence tomography. Brain 2009;132(Pt 3):628-34. 4. Gelfand JM, Nolan R, Schwartz DM, et al. Microcystic macular oedema in multiple sclerosis is associated with disease severity. Brain 2012;135(Pt 6):1786-93. 5. Ledda F, Paratcha G. Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins. Front Cell Neurosci 2016;10:199. |
| Language |
eng |
| Format |
application/pdf |
| Format Creation |
Microsoft PowerPoint |
| Type |
Text |
| Source |
49th Annual North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2023: Insight Into Neuroanatomy: Learning From Pediatric Neuro-Ophthalmic Disorders: https://novel.utah.edu/collection/NAM/toc/ |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890 |
| Rights Management |
Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6jkhzc6 |
| Setname |
ehsl_novel_nam |
| ID |
2386632 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6jkhzc6 |
