| Identifier |
20230315_nanos_surgery1_06 |
| Title |
Should I Have Teprotumumab or Surgery? |
| Creator |
Alison V. Crum, MD |
| Affiliation |
John A. Moran Eye Center, University of Utah, Salt Lake City, UT |
| Subject |
Thyroid Orbitopathy; Thyroid Eye Disease; Teprotumumab; Proptosis; Diplopia |
| Description |
Pathophysiology of thyroid eye disease/thyroid orbitopathy and teprotumumab: In orbitopathy, it is believed that there is a cross reaction of thyroid auto-antibodies with the thyrotropin receptor (TSHR) and the insulin growth factor receptor (IGFR) on orbital fibroblasts. |
| Date |
2023-03 |
| References |
[1] Douglas, R. S. et al. Teprotumumab for the Treatment of Active Thyroid Eye Disease. New England Journal of Medicine 2020; 382:341-352. doi: 10.1056/NEJMoa1910434 [2] Douglas, R. S. et al. Teprotumumab Efficacy, Safety, and Durability in Longer- Duration Thyroid Eye Disease and Re-Treatment. Ophthalmology April 2022; 129(4): 438-449. doi: 10.1016/j.ophtha.2021.10.017 [3] Haymart, Megan R. Year in Thyroidology-Recent Developments and Future Challenges: Clinical Science Review. Thyroid 2022 32(1):9-13. doi: 10.1089/thy.2021.0562 [4] Bhatti and Dutton. Thyroid Eye Disease: Therapy in the Active Phase. J Neuro- ophthalmol 2014; 34: 186-197. doi: 10.1097/wno.0000000000000128 [5] Marta Calsina Prat, Alexandra L Braunstein, Lora R Dagi Glass, Michael Kazim. Orbital fat decompression for thyroid eye disease: retrospective case review and criteria for optimal case selection. Ophthalmic Plast Reconstr Surg. 2015 May- Jun;31(3):215-8. doi: 10.1097/IOP.0000000000000260. |
| Language |
eng |
| Format |
application/pdf |
| Format Creation |
Microsoft PowerPoint |
| Type |
Text |
| Source |
49th Annual North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2023: Ophthalmic Surgery in the Neuro-Ophthalmic Patient: https://novel.utah.edu/collection/NAM/toc/ |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890 |
| Rights Management |
Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6vvwggh |
| Setname |
ehsl_novel_nam |
| ID |
2386620 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6vvwggh |
