| Identifier |
20230315_nanos_neuroimmunology1_01 |
| Title |
MS and the Immune System |
| Creator |
Jennifer Graves, MD, PhD, MAS |
| Affiliation |
UCSD, San Diego, CA |
| Subject |
Multiple Sclerosis; Autoimmunity; Genetics; Aging; Sex Differences |
| Description |
Multiple sclerosis is a multifactorial autoimmune disease of the central nervous system with three primary targets of the brain, spinal cord and optic nerves. Based on monozygotic twin studies, the heritability of MS is 25%. Over the last decade of advances in genome wide association studies, 48% of that heritability has now been explained by > 200 MS risk alleles, the majority of which are associated with immune genes. The closest genetic cousins of MS are other autoimmune diseases and not neurodegenerative diseases. |
| Date |
2023-03 |
| References |
1. International MS Genetics Consortium. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility Science 2019. Vol 365; No. 6460. Sept 27. 2. Fitzgerald, KC, et al. Early complement genes are associated with visual system degeneration in multiple sclerosis. Brain 2019. Vol 142. Pages 2722-2736. Sept 1. 3. Attfield, KE, Jensen, LT, kaufman, M, Friese, MA, Fugger, L. The Immunology of Multiple Sclerosis. Nature Reviews Immunology 2022. May 4th. 4. Graves, JS, Krysko, KM, Hua, LH, Absinta, M, Franklin, JM, Segal, BM. Ageing and Multiple Sclerosis. Lancet Neurology. Oct 7 2022. Online First. 5. Krysko KM, Henry RG, Cree BAC, et al. Telomere length is associated with disability progression in multiple sclerosis. Ann Neurol 2019; 86: 671-82. |
| Language |
eng |
| Format |
application/pdf |
| Format Creation |
Microsoft PowerPoint |
| Type |
Text |
| Source |
49th Annual North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2023: Neuroimmunology: https://novel.utah.edu/collection/NAM/toc/ |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890 |
| Rights Management |
Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6fgjtpb |
| Setname |
ehsl_novel_nam |
| ID |
2386611 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6fgjtpb |
