| Identifier |
20230314_nanos_sciplatform2_01 |
| Title |
VRDN-001, a Full Antagonist Antibody to IGF-1 Receptor for Thyroid Eye Disease (TED): Phase 1/2 Clinical Study in Patients |
| Creator |
Raymond Douglas; Kimberley Cockerham; Roger Turbin; Rosa Tang; Navdeep Nijhawan Shoaib Ugradar; Denis O'Shaughnessy; Rochelle Summerfelt; Angela She; Barrett Katz |
| Affiliation |
(RD) (SU) Cedars Sinai Medical Center; (KC) Senta Clinic; (RT) Rutgers New Jersey Medical School - Department of Ophthalmology & Visual Science; (RT) Eye Wellness Center- Neuro-Eye Clinical Trials, Inc.; (NN) Oshawa Clinic; (DO) (RS) (AS) (BK) Viridian Therapeutics Inc. |
| Subject |
Graves' Disease; Neuro-ophthalmology & Systemic Disease (eg. MS, MG, Thyroid); Orbit/Ocular Pathology |
| Description |
Clinical and preclinical evidence confirms IGF-1R antagonism reduces TED-related inflammation and proptosis. VRDN-001, a full antagonist antibody to IGF-1R, is being evaluated in a phase 1/2 double-masked, randomized clinical trial (NCT05176639) at 3, 10, or 20 mg/kg administered intravenously. Results from the first cohort of TED patients are presented here. |
| Date |
2023-03 |
| References |
None provided. |
| Language |
eng |
| Format |
application/pdf |
| Format Creation |
Microsoft PowerPoint |
| Type |
Text |
| Source |
2023 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2023: Scientific Platform Session II: https://novel.utah.edu/collection/NAM/toc/ |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6g6evpj |
| Setname |
ehsl_novel_nam |
| ID |
2386591 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6g6evpj |
