Neuro-Muscular Disease and the Immune System
| Identifier | 20230315_nanos_neuroimmunology1_03 |
| Title | Neuro-Muscular Disease and the Immune System |
| Creator | Umapathi Thirugnanam, MD |
| Affiliation | National Neuroscience Institute, Singapore |
| Subject | Stiff Person Syndrome; Tetanus; Anti-MuSK ab MG; Guillain-Barré Syndrome; Diphtheric Neuropathy |
| Description | The interneuron plays an integral role in the dance between agonist and antagonist muscles, alternating contraction and relaxation of skeletal muscles for smooth motor functions. In stiff-person syndrome, an autoimmune process disrupts the proper functioning of the spinal interneurons, resulting in cocontraction of agonist and antagonist muscles. Patients may have raised anti-glutamic acid decarboxylase (GAD) or anti-amphiphysin antibodies, the former associated with thymoma; the latter a marker of more general paraneoplastic phenomena. |
| Date | 2023-03 |
| References | 1. Dalakas MC, Fujii M, Li M, McElroy B. The clinical spectrum of anti-GAD antibody-positive patients with stiff-person syndrome. Neurology. 2000 Nov 28;55(10):1531-5. 2. Bhatia R, Prabhakar S, Grover VK. Tetanus. Neurol India. 2002 Dec;50(4):398-407. 3. Waters P, Woodhall M, Coutinho E, Balint B, Lang B, Pettingill P, Carr A, Sheerin UM, Press R, Press R, Lunn MP, Lim M, Maddison P, Meinck HM, Vandenberghe W, Vincent A. Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes. Brain.2014 Aug;137(Pt 8):2178-92. Erratum in: Brain. 2014 Dec;137(Pt 12):e315. Erratum in: Brain. 2014 Jan;137(Pt 1):1. 4. Hutchinson M, Waters P, McHugh J, Gorman G, O'Riordan S, Connolly S, Hager H, Yu P, Becker CM, Vincent A. Progressive encephalomyelitis, rigidity, and myoclonus: a novel glycine receptor antibody. Neurology. 2008 Oct 14;71(16):1291-2. 5. Dekker MC, Urasa SJ, Kinabo G, Maro V, Howlett WP. A Report of Stiff Person Syndrome in Tanzania with First Epidemiological Figures for Sub-Saharan Africa. Neuroepidemiology. 2015;45(2):109-10. |
| Language | eng |
| Format | video/mp4 |
| Type | Image/MovingImage |
| Source | 49th Annual North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of | NANOS Annual Meeting 2023: Neuroimmunology: https://novel.utah.edu/collection/NAM/toc/ |
| Collection | Neuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher | North American Neuro-Ophthalmology Society |
| Holding Institution | Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890 |
| Rights Management | Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK | ark:/87278/s6jrd81k |
| Setname | ehsl_novel_nam |
| ID | 2386005 |
| Reference URL | https://collections.lib.utah.edu/ark:/87278/s6jrd81k |