Functional and Structural ipRGC Alterations Across Alzheimer's Disease Pathological Stages
| Identifier | 20230314_nanos_sciplatform2_05 |
| Title | Functional and Structural ipRGC Alterations Across Alzheimer's Disease Pathological Stages |
| Creator | Nicolae Sanda; Dan Milea; Eniko Kövari; Andreas Kleinschmidt; Gabriele Thumann; Sonja Kleinlogel; Ludovic Mure |
| Affiliation | (NS) (EK) (AK) (GT) Geneva University Hospital; (DM) Singapore National Eye Centre; (SK) University of Bern; (LM) Bern University |
| Subject | Retina; Orbit/Ocular Pathology; Pupil; Miscellaneous |
| Description | Non-image-forming photoreception, driven by intrinsically photosensitive retinal ganglion cells (ipRGCs) is critical in functions like circadian entrainment and the modulation of sleep/alertness, and mood. Disruption of sleep and circadian rhythms is one of the earliest symptoms of Alzheimer's disease (AD), but little is known about the role of ipRGCs in this process. Our study aimed to evaluate the pathophysiology of the disrupted circadian connections in AD, by exploring structural and functional characteristics of ipRGCs in postmortem specimens from patients with various degrees of AD neuropathological alterations. |
| Date | 2023-03 |
| References | Mure, L. S., Vinberg, F., Hanneken, A., & Panda, S. . Functional diversity of human intrinsically photosensitive retinal ganglion cells. Science, 366(6470), 1251-1255, 2019 Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., ... & Montine, T. J. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimer's & dementia, 8(1), 1-13, 2012. La Morgia, C., Ross-Cisneros, F. N., Koronyo, Y., Hannibal, J.,... & Carelli, V. Melanopsin retinal ganglion cell loss in A lzheimer disease. Annals of neurology, 79(1), 90-109, 2016. Chougule, P. S., Najjar, R. P., Finkelstein, M. T., Kandiah, N., & Milea, D. Light-induced pupillary responses in Alzheimer's disease. Frontiers in neurology, 10, 360, 2019. |
| Language | eng |
| Format | video/mp4 |
| Type | Image/MovingImage |
| Source | 49th Annual North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of | NANOS Annual Meeting 2023: Scientific Platform Session II: https://novel.utah.edu/collection/NAM/toc/ |
| Collection | Neuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher | North American Neuro-Ophthalmology Society |
| Holding Institution | Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890 |
| Rights Management | Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK | ark:/87278/s6e03qrf |
| Setname | ehsl_novel_nam |
| ID | 2385985 |
| Reference URL | https://collections.lib.utah.edu/ark:/87278/s6e03qrf |