NOVEL - NANOS Annual Meeting

VRDN-001, a Full Antagonist Antibody to IGF-1 Receptor for Thyroid Eye Disease (TED): Phase 1/2 Clinical Study in Patients

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Identifier 20230314_nanos_sciplatform2_01
Title VRDN-001, a Full Antagonist Antibody to IGF-1 Receptor for Thyroid Eye Disease (TED): Phase 1/2 Clinical Study in Patients
Creator Raymond Douglas; Kimberley Cockerham; Roger Turbin; Rosa Tang; Navdeep Nijhawan Shoaib Ugradar; Denis O'Shaughnessy; Rochelle Summerfelt; Angela She; Barrett Katz
Affiliation (RD) (SU) Cedars Sinai Medical Center; (KC) Senta Clinic; (RT) Rutgers New Jersey Medical School - Department of Ophthalmology & Visual Science; (RT) Eye Wellness Center- Neuro-Eye Clinical Trials, Inc.; (NN) Oshawa Clinic; (DO) (RS) (AS) (BK) Viridian Therapeutics Inc.
Subject Graves' Disease; Neuro-ophthalmology & Systemic Disease (eg. MS, MG, Thyroid); Orbit/Ocular Pathology
Description Clinical and preclinical evidence confirms IGF-1R antagonism reduces TED-related inflammation and proptosis. VRDN-001, a full antagonist antibody to IGF-1R, is being evaluated in a phase 1/2 double-masked, randomized clinical trial (NCT05176639) at 3, 10, or 20 mg/kg administered intravenously. Results from the first cohort of TED patients are presented here.
Date 2023-03
References None provided.
Language eng
Format video/mp4
Type Image/MovingImage
Source 2023 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS Annual Meeting 2023: Scientific Platform Session II: https://novel.utah.edu/collection/NAM/toc/
Collection Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s63p04fw
Setname ehsl_novel_nam
ID 2385981
Reference URL https://collections.lib.utah.edu/ark:/87278/s63p04fw
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