Ocular Coherence Tomography Retinal Analysis in Pituitary Adenoma Cases with Chiasmal Compression

To determine the alteration in ganglion cell complex and its relationship with retinal nerve fibre layer (RNFL) thickness as measured by spectral domain optical coherence tomography (OCT) in pituitary adenoma cases and also its correlation with visual field (VF).

Poster 308 Ocular Coherence Tomography retinal analysis in Pituitary Adenoma cases with chiasmal compression Rachna Agarwal 1 1 Sanjay Gandhi Post Graduate Institute of Medical Sciences Introduction: To determine the alteration in ganglion cell complex and its relationship with retinal nerve fibre layer (RNFL) thickness as measured by spectral domain optical coherence tomography (OCT) in pituitary adenoma cases and also its correlation with visual field (VF). Methods: : This is a prospective comparative study wherein detailed neuro-ophthalmic examination including perimetry, RNFL and ganglion cell layer inner plexiform layer (GCL-IPL) thickness were measured preoperatively and postoperatively in the cases of pituitary adenoma with chiasmal compression . GCL-IPL, RNFL parameters were compared with controls and were correlated with visual field mean deviation (MD). Results: Twenty-four patients qualified the inclusion criteria. A significant thinning of GCL-IPL (P 0.002) and RNFL (P 0.039) was noticed in the pituitary adenoma group. GCL-IPL (r = 0.780 P < 0.001) and RNFL (r = 0.669, P < 0.001) were significantly correlated with the MD. The ROC curve values of GCL-IPL were 0.859 (95% Confidence Interval 0.744% to 0.973) and of RNFL were 0.731 (95% Confidence Interval 0.585 – 0.877). The diagnostic ability of GCL-IPL was more compared to the RNFL analysis although it was statistically insignificant (P 0.122). Conclusions: GCL-IPL measurements on the OCT is a sensitive tool to detect early anterior visual pathway changes in chiasmal compression for pituitary adenoma patients. References: None provided. Keywords: Diagnostic tests (ERG, VER, OCT, HRT, mfERG, etc), Neuroimaging, Retina, Tumors, Visual fields Financial Disclosures: The authors had no disclosures. Grant Support: None. Contact Information: Rachna Agarwal, [e-mail] 498 | North American Neuro-Ophthalmology Society