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Show Poster 262 A Pilot Study of Optical Filters for the Treatment of Sharp Edge Eye Syndrome Merrick Reynolds 1, Thomas Dowdle 1, Azraa Ayesha 1, Judith Warner 2, Kathleen Digre 3, Meagan Seay 4, Bradley Katz 5 University of Utah School of Medicine, 2 University of Utah Health, Moran Eye Center, 3 University of Utah, 4 University of Utah, Moran Eye Center, 5 John A Moran Eye Center; University of Utah Health 1 Introduction: Sharp Edge Eye Syndrome (SEES), sometimes known as visual looming syndrome, is an idiopathic condition in which the patient experiences ocular pain or discomfort when viewing or mentally picturing sharp objects and edges. The purpose of this study was to determine if an optical filter could improve vision-related quality of life (VRQoL) in patients with SEES. Because photophobia is partially driven by intrinsically photosensitive retinal ganglion cells (IPRGCs), we used an optical filter that maximally blocked light at 480 nm and 590 nm, the wavelengths that activate IPRGCs. Methods: This study was approved by the University of Utah IRB. Our goal was to recruit ten subjects using Reddit and Facebook, online forums that include platforms for SEES. Eligible subjects completed the National Eye Institute Visual Function Questionnaire (VFQ-25), Utah Photophobia Symptom Impact Scale (UPSIS-12), ID migraine, General Anxiety Disorder-2 (GAD-2), and Personal Health Questionnaire (depression) Scale-2 (PHQ-2). Lenses were mounted into frames and shipped to subjects. Subjects were asked to wear the glasses for 75% of waking hours for six weeks. At the end of the study, subjects again completed the VFQ-25. The primary endpoint was change in VFQ25. Subjects were given the option of keeping the glasses or returning them in exchange for a $100 Amazon gift card. Results: Eight subjects (6 male and 2 female) completed all study instruments, two were lost to follow up. The average baseline VFQ-25 mean composite score was 74.2. The average post-study VFQ-25 score was 82.1. This improvement in score was statistically significant (p=0.005). Of the eight subjects, five kept the lenses and three returned them in exchange for the gift card. Conclusions: We observed significant improvement in VRQoL when SEES subjects wore an optical filter. Our preliminary results support conducting a larger trial to confirm the effectiveness of these filters. References: 1. Reynolds MS, Katz BJ, Digre KB, Brintz BJ, Olson LM, Warner JEA. Sharp Edge Eye Syndrome: A Case Report and Survey of Self-Identified Individuals. J Neuro-ophthalmology. 2022 Jul 11. Doi: 10.1097/WNO.0000000000001650 PMID: 36166802. Keywords: Miscellaneous, Visual fields, Higher visual functions Financial Disclosures: Merrick Reynolds: No; Thomas Dowdle: No; Azraa Ayesha: No; Judith Warner: I receive royalties from patents describing the use of optical filters for the treatment of light sensitivity.; Kathleen Digre: Dr. Digre receives royalties from patents describing the use of optical filters for the treatment of light sensitivity; Meagan Seay: No; Bradley Katz: Dr. Katz is CMO of Axon Optics, an online company that develops, markets and sells eyewear for the treatment of light sensitive conditions. Dr. Katz receives royalties from patents that describe the use of optical filters for the treatment of light sensitive conditions. Grant Support: Supported in part by an unrestricted grant from Research to Prevent Blindness Inc. New York, New York to the Department of Ophthalmology and Visual Sciences. Contact Information: Merrick Reynolds, Merrick.Reynolds@hsc.utah.edu 450 | North American Neuro-Ophthalmology Society |
