Identifier |
20230312_nanos_posters_182 |
Title |
Downbeat Nystagmus and Ataxia Preceding New-Onset Type 1 Diabetes Mellitus - Role of Anti-GAD Antibodies? |
Creator |
Gary Salomon; Emily Schofield; Terisa Yiin; Aimee Szewka |
Affiliation |
(GS) (ES) (TY) University of Central Florida College of Medicine; (AS) Rush Medical College |
Subject |
Neuro-ophthalmology & Systemic Disease (eg. MS, MG, Thyroid); Nystagmus; Ocular Motility |
Description |
Autoantibodies to glutamic acid decarboxylase (anti-GAD Abs) are prevalent in diabetes mellitus type 1 (T1DM) and often considered a biologic marker of this disease. High titers of anti-GAD Abs have also been described in multiple neurological syndromes, including stiff-person syndrome, cerebellar ataxia, and epilepsy-syndromes which are considered to result from reduced γ-aminobutyric acid (GABA) transmission. However, the pathophysiology underlying the role of anti-GAD Ab in these relatively rare neurological syndromes remains poorly understood and no criteria exist to establish when a neurological syndrome is pathogenically linked to anti-GAD Ab, sometimes resulting in misdiagnosis and unnecessary treatment. Here, we report a patient presenting with cerebellar ataxia who developed late-onset T1DM with high anti-GAD Ab titers. |
Date |
2023-03-14 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2023 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2023: Poster Session I: Neuro-Ophthalmic Disorders of Neurologic and Systemic Diseases |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6fby0cr |
Setname |
ehsl_novel_nam |
ID |
2335388 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6fby0cr |