| Identifier |
20230312_nanos_posters_112 |
| Title |
Successful Treatment of Trigeminal Perineural Invasion by Cutaneous Squamous Cell Carcinoma with Cemiplimab Monotherapy |
| Creator |
Andrew Carey; Nicholas Mahoney |
| Affiliation |
(AC) Johns Hopkins Wilmer Eye Institute; (NM) Johns Hopkins University School of Medicine |
| Subject |
Skull Base; Tumors; Ocular Motility; Orbit; Orbit/ocular Pathology |
| Description |
Head and neck squamous cell carcinoma (SqCCa) is prone to perineural invasion and as such may spread along the branches of the trigeminal nerve into the orbit, superior orbital fissure, cavernous sinus, and along dura presenting with pain, numbness, vision loss, and motor cranial neuropathies. Cemiplimab is an anti-PD-1 monoclonal antibody that has been FDA approved for treatment of unresectable cutaneous SqCCa. |
| Date |
2023-03-14 |
| References |
1. Migden MR, Rischin D, Schmults CD, et al. PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma. N Engl J Med. 2018 Jul 26;379(4):341-351. 2. McLean LS, Lim AM, Webb A, et al. Immunotherapy to Avoid Orbital Exenteration in Patients With Cutaneous Squamous Cell Carcinoma. Front Oncol. 2022 Jan 18;11:796197. 3. Clark TJE, Harris GJ. Management of periocular cutaneous squamous cell carcinoma with perineural invasion: a case series and literature review. Orbit. 2022 Feb;41(1):34-43. 4. Demirci H, Elner VM, Demirci FY, et al. Immunotherapy for Conjunctival Squamous Cell Carcinoma with Orbital Extension. Ophthalmology. 2021 May;128(5):801-804. |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2023 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2023: Poster Session I: Ocular Motility Disorders and Nystagmus |
| Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Rights Management |
Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6k3tkhx |
| Setname |
ehsl_novel_nam |
| ID |
2335318 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6k3tkhx |
