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Show Poster 41 When My Green Eye Turns Brown: Uveitis-Glaucoma-Hyphema Syndrome Causing Transient Monocular Heterochromia and Vision Loss Mohamed Khodeiry 1, Kristen Minkowski 2, Shahnaz Miri 2, David Greenfield 2, Byron Lam 2 1 Children's Hospital of Pittsburgh, 2 Bascom Palmer Eye Institute Introduction: Transient monocular vision loss (TMVL) can be due to multiple etiologies. The causes could be vascular, neurologic, or ophthalmic. We report a unique case of recurrent transient monocular iris heterochromia, and transient monocular vision loss (TMVL) due to UGH syndrome. Description of Cases: A 66-year-old woman presented with TMVL associated with transient iris color change from green to brown in her left eye. The patient underwent bilateral cataract surgery and intraocular lens (IOL) implantation 2 years prior to her initial presentation. Past medical history was positive for medically controlled systemic hypertension. Extensive neurodiagnostic imaging and blood work-up were unremarkable except for hypercholesterolemia. Ophthalmic examination revealed best-corrected visual acuity of 20/15 in each eye and intraocular pressure of 13 mm Hg and 10 mm Hg, in right and left eyes, respectively. Anterior segment examination revealed bilateral light-colored irides, with iris transillumination defects and a 1-piece posterior chamber IOL with haptic in the ciliary sulcus in the left eye. Gonioscopy revealed an open angle and dense trabecular pigmentation in the left eye. Personal photographs taken by the patient during episodes of transient vision loss were reviewed and demonstrated iris heterochromia consistent with unilateral hyphema in the left eye, and a diagnosis of UGH syndrome was established. Intraocular lens repositioning was performed resulting in complete resolution of TMVL and transient iris heterochromia in the left eye. Conclusions, including unique features of the case: TMVL associated with transient iris heterochromia may be a feature of UGH syndrome. Careful history, examination of the anterior segment and ancillary testing are essential to diagnose this uncommon condition. References: None provided. Keywords: Vascular disorders, Neuroimaging Financial Disclosures: The authors had no disclosures. Grant Support: None. Contact Information: None provided. 106 | North American Neuro-Ophthalmology Society |
