| Identifier |
20230316_nanos_pathway1_05 |
| Title |
Structural Correlates of Amblyopia |
| Creator |
Eric D. Gaier, MD, PhD |
| Affiliation |
Boston Children's Hospital, Harvard Medical School, Boston, MA |
| Subject |
Amblyopia; OCT-Angiography; Lateral Geniculate Nucleus; Retinal Silencing; Ocular Dominance Columns |
| Description |
Amblyopia has long been defined as visual impairment without an 'organic' cause, referring to anatomic and/or structural pathology. There is a growing body of evidence, enabled by technological and scientific advancement, that structural correlates to amblyopia exist from the retina to high-order visual brain regions. I will review foundational and recent findings across basic and translational sciences and along the canonical visual pathway from the retina to the visual cortex. |
| Date |
2023-03 |
| References |
1. Gaier ED, Gise R, Heidary G. Imaging Amblyopia: Insights from Optical Coherence Tomography (OCT). Semin Ophthalmol. 2019;34(4):303-311. 2. Wong ES, Zhang XJ, Yuan N, Li J, Pang CP, Chen L, Tham CC, Cheung CY, Yam JC. Association of Optical Coherence Tomography Angiography Metrics With Detection of Impaired Macular Microvasculature and Decreased Vision in Amblyopic Eyes: The Hong Kong Children Eye Study. JAMA Ophthalmol. 2020 Aug 1;138(8):858-865. 3. Bear MF, Colman H. Binocular competition in the control of geniculate cell size depends upon visual cortical N-methyl-D-aspartate receptor activation. Proc Natl Acad Sci U S A. 1990 Dec;87 (23):9246-9. 4. Fong MF, Mitchell DE, Duffy KR, Bear MF. Rapid recovery from the effects of early monocular deprivation is enabled by temporary inactivation of the retinas. Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14139-14144. 5. Fong MF, Duffy KR, Leet MP, Candler CT, Bear MF. Correction of amblyopia in cats and mice after the critical period. Elife. 2021 Aug 31;10:e70023. |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2023 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2023: Insight Into Neuroanatomy: Learning From Pediatric Neuro-Ophthalmic Disorders |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6cvzzb5 |
| Setname |
ehsl_novel_nam |
| ID |
2309988 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6cvzzb5 |
