Effects of Idebenone on Color Vision in Patients With Leber Hereditary Optic Neuropathy

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Title Effects of Idebenone on Color Vision in Patients With Leber Hereditary Optic Neuropathy
Creator Rudolph, Guenther; Dimitriadis, Konstantinos; Bochner, Boriana; Heck, Suzette; Al-Tamami, Jasmina; Seidensticker, Florian; Rummey, Christian; Leinonen, Mika; Meier, Thomas; Klopstock, Thomas
Affiliation Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians-University, Munich, Germany; Santhera Pharmaceuticals, Liestal, Switzerland; and 4Pharma, Stockholm, Sweden
Subject Adolescent; Adult; Antioxidants; Color Perception; Double-Blind Method; Female; Humans; Male; Middle Aged; Optic Atrophy, Hereditary, Leber; Pigmentation Disorders; Skin Diseases, Genetic; Treatment Outcome; Ubiquinone
Abstract The authors investigated the correlation of protan and tritan color vision with disease characteristics in Leber hereditary optic neuropathy (LHON). The authors also characterized the therapeutic potential of idebenone in protecting patients from developing dyschromatopsia in LHON. Color contrast data of 39 LHON patients participating in a randomized, double-blind placebo-controlled intervention study were evaluated. Patients reported disease onset ,5 years before enrollment and were genetically confirmed. Protan and tritan color contrast sensitivity was measured using a computer graphics method in patients.
OCR Text Show
Date 2013-03
Type Text
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s6w69rvc
Setname ehsl_novel_jno
Date Created 2014-03-24
Date Modified 2014-07-10
ID 227375
Reference URL https://collections.lib.utah.edu/ark:/87278/s6w69rvc
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