Pancreatic Neuroendocrine Paraneoplastic Optic Neuropathy: Confirmation with Antibody to Optic Nerve and Hepatic Metastasis

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Title Pancreatic Neuroendocrine Paraneoplastic Optic Neuropathy: Confirmation with Antibody to Optic Nerve and Hepatic Metastasis
Creator Slamovits, Thomas L; Posner, Jerome B; Reidy, Diane L; Thirkill, Charles E; Keltner, John L
Affiliation Department of Ophthalmology, Neurology and Neurosurgery, Albert Einstein College of Medicine, Bronx, New York; Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York; Ocular Immunology Laboratory, Department of Ophthalmology and Vision Science, University of California Davis, Davis, California; and Department of Ophthalmology and Vision Science, Neurology and Neurosurgery, University of California Davis Medical Center, Sacramento, California
Subject Aged; Female; Humans; Neuroendocrine Tumors; Optic Nerve; Optic Nerve Diseases; Pancreatic Neoplasms; Paraneoplastic Syndromes, Ocular; Vision Disorders; Visual Acuity
Abstract A 68-year-old woman presented with bilateral visual loss as the only clinical manifestation of an occult pancreatic nonsecretory neuroendocrine tumor (NET). The suspected diagnosis of paraneoplastic optic neuropathy was confirmed using immunofluorescence assays to demonstrate the presence of antibodies in the patient's serum that reacted with antigen(s) in the optic nerve and in the pancreatic NET hepatic metastasis. Treatment of the underlying cancer was followed by marked improvement in visual function.
OCR Text Show
Date 2013-03
Type Text
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s64n29n9
Setname ehsl_novel_jno
Date Created 2014-03-24
Date Modified 2014-07-28
ID 227373
Reference URL https://collections.lib.utah.edu/ark:/87278/s64n29n9
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