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LITERATURE ABSTRACTS 179 Papillopathy Caused by Amiodarone. Gittinger JW, Asdourian GK. Arch OphthalmoI1987;105:34951 (Mar). [Reprints not available.] Two patients taking amiodarone for cardiac arrhythmia presented with minimal visual dysfunction and optic nerve edema with hemorrhages, unilateral in one and bilateral in the other. In one patient the disk edema resolved spontaneously but in the other edema did not resolve until amiodarone was discontinued. In the patient with bilateral disk edema, lumbar puncture was not performed although pseudotumor cerebri has been reported with amiodarone use. Although such edema has been reported with other drugs of this class, the authors have examined -150 patients taking amiodarone in 8 years and these are their only cases of optic nerve edema. Lyn A. Sedwick, M.D. Acute Severe Irreversible Visual Loss with Sphenoethmoiditis-"Posterior" Orbital Cellulitis. Slavin ML, Glaser JS. Arch Ophthalmol 1987;105: 345-8 (Mar). [Reprint requests to Dr. M. L. Slavin, Division of Neuro-ophthalmology, Department of Ophthalmology, Long Island Jewish Medical Center, New Hyde Park, NY 11042.] Three patients are discussed with visual loss, and two patients with a motility disorder ultimately were found to have sphenoethmoiditis. Adnexal signs (lid edema or proptosis) were mildly present in each patient; surgical drainage resulted in no improvement in vision in two patients. The authors discuss this entity, which they labeled "posterior orbital cellulitis," and postulate that its relative rarity relates to orbit- sinus anatomy, which may allow spread to the anterior orbit from the sinus but rarely to the posterior orbit. They recommend early surgical intervention. Lyn A. Sedwick, M.D. Ophthalmologic Manifestations of X-linked Childhood Adrenoleukodystrophy. Traboulsi EI, Maumenee IH. Ophthalmology 1987;94:47-52 Gan). [Reprint requests to I. H. Maumenee, M.D., Wilmer Eye Institute, Maumenee Building, Room 321, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21205.] This report catalogues ophthalmologic findings in 15 patients with childhood adrenoluekodystrophy referred to the authors between 1980 and 1985. Follow-up ranged from 1 to 36 months and age at referral ranged from 4.5 to 18 years. Vision was quite variable (20/20 to no light perception) and extraocular muscle imbalance was common (two-thirds of the patients, usually exotropia). Patients with abnormal visual function usually had optic atrophy, but some had hemianopic visual field defects. A very extensive discussion section reviews the four clinical variants of adrenoleukodystrophy and recommends considering this diagnosis in male children with visual loss, dementia, or scholastic failure. Lyn A. Sedwick, M.D. Two Cases of Downbeat Nystagmus and Oscillopsia Associated with Carbamazepine. Chrousos GA, Cowdry R, Schuelein M, Abdul-Rahim AS, Matsuo V, Currie IN. Am J Ophthalmol 1987;103: 221-4 (Feb). [Reprint requests to Dr. G. A. Chrousos, Georgetown University Medical Center, 5 Kober-Cogan Building, 3800 Reservoir Rd., N.W., Washington, DC 20007.] Two patients taking Tegretol (carbamazepine) for seizure disorders were found to have downbeat nystagmus in primary position which resolved with decreasing or discontinuing the drug. Magnetic resonance imaging was normal in both patients. Lyn A. Sedwick, M.D. I ChI' Neuro-ophthalmol, Vol. 7, No.3. 1987 |
