| Title |
Paraneoplastic Optic Neuropathy and Autoantibody Production in Small-Cell Carcinoma of the Lung |
| Creator |
Luiz, JE; Lee, AG; Keltner, JL; Thirkill, CE; Lai, EC |
| Affiliation |
Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA. |
| Abstract |
A 59-year-old woman presented with acute-onset, bilateral, painless loss of vision, dysarthria, and ataxia. Ophthalmoscopy showed bilateral optic disc edema. A magnetic resonance scan of the head was normal. Chest radiography showed mediastinal adenopathy. Mediastinoscopy and biopsy identified small-cell carcinoma of the lung. An autoantibody to optic nerve and retina was demonstrated in the patient's serum. An electroretinogram was normal. The patient was diagnosed with a paraneoplastic optic neuropathy and paraneoplastic cerebellar syndrome. After treatment for her lung cancer, the patient remains stable from a visual and neurologic standpoint. |
| Subject |
Acute Disease; Autoantibodies/analysis; Carcinoma, Small Cell/immunology; Carcinoma, Small Cell/pathology; Electroretinography; Female; Humans; Lung Neoplasms/immunology; Lung Neoplasms/pathology; Middle Older people; Optic Nerve/immunology; Optic Nerve Diseases/diagnosis; Optic Nerve Diseases/immunology; Paraneoplastic Syndromes/diagnosis; Paraneoplastic Syndromes/immunology; Retina/immunology; Vision Disorders/diagnosis; Visual Fields |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
224933 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6nc968p/224933 |
