Identifier |
20220215_nanos_sciplatform3_07 |
Title |
Retrograde Transport to Retinal Ganglion Cells: An Alternative Strategy for Gene Delivery in Optic Neuropathies |
Creator |
Jonathan Horton; Mikayla Dilbeck; John Economides; Rakesh Nanjappa |
Affiliation |
(JH) (MD) (JE) (RN) UCSF, San Francisco, California |
Subject |
Genetic Disease; Optic Neuropathy |
Description |
The internal limiting membrane represents a major obstacle to successful transduction of retinal ganglion cells by adeno-associated virus (AAV) for treatment of Leber's hereditary optic neuropathy. Recombinant AAV2-retro is a variant of AAV serotype 2 developed explicitly for retrograde transport. In preparation for planned studies in non-human primates, we report gene expression in retinal ganglion cells following injection of rAAV2-retro into the rat superior colliculus. |
Date |
2022-02 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2022 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2022: Scientific Platform III |
Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
Publisher |
North American Neuro-Ophthalmology Society |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
Copyright 2022. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s67ckzfm |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
2205272 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s67ckzfm |