NOVEL - NANOS Annual Meeting

Retrograde Transport to Retinal Ganglion Cells: An Alternative Strategy for Gene Delivery in Optic Neuropathies

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Identifier 20220215_nanos_sciplatform3_07
Title Retrograde Transport to Retinal Ganglion Cells: An Alternative Strategy for Gene Delivery in Optic Neuropathies
Creator Jonathan Horton, Mikayla Dilbeck, John Economides, Rakesh Nanjappa
Subject Genetic Disease; Optic Neuropathy
Description The internal limiting membrane represents a major obstacle to successful transduction of retinal ganglion cells by adeno-associated virus (AAV) for treatment of Leber's hereditary optic neuropathy. Recombinant AAV2-retro is a variant of AAV serotype 2 developed explicitly for retrograde transport. In preparation for planned studies in non-human primates, we report gene expression in retinal ganglion cells following injection of rAAV2-retro into the rat superior colliculus.
Date 2022-02
Language eng
Format video/mp4
Type Image/MovingImage
Source 2022 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS Annual Meeting 2022: Scientific Platform III
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Rights Management Copyright 2022. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6f6gsf1
Context URL The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/
Contributor Primary Jonathan Horton, MD, PhD
Contributor Secondary Mikayla Dilbeck, John Economides, Rakesh Nanjappa
Setname ehsl_novel_nam
ID 2187021
Reference URL https://collections.lib.utah.edu/ark:/87278/s6f6gsf1
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