One Eye or Two: Statistical Considerations in Ophthalmology With a Focus on Interventional Clinical Trials

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Title One Eye or Two: Statistical Considerations in Ophthalmology With a Focus on Interventional Clinical Trials
Creator Susan P. Mollan, FRCOphth; Victoria Homer, MsC; Simon Gates, PhD; Kristian Brock, PhD; Alex J. Sinclair, PhD
Affiliation Birmingham Neuro-Ophthalmology (SPM), Queen Elizabeth Hospital, Birmingham, United Kingdom; Cancer Research UK Clinical Trials Unit (CRCTU) (VH, SG, KB), University of Birmingham, Birmingham, United Kingdom; Metabolic Neurology (AJS), Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; Centre for Endocrinology (AJS), Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom; and Department of Neurology (AJS), Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdo
Abstract Research in ophthalmology is unusual in comparison with other many medical specialties by having 2 targets where frequent and accessible data can be collected and analyzed. The major factor is that 2 eyes are not independent as they belong to the same individual. As many statistical methods assume independence of observations, historically, many researchers have arbitrarily chosen one eye for analysis. Another approach to maintain independence of observations is to generate subject level index variables using information from both eyes. This was the approach taken by Anagnostou et al in this issue of Journal of Neuro-ophthalmology. Specifically, for measurements taken in both eyes of subjects with 3 possible grades (i.e., 0, 1, 2 in the right eye and 0, 1, 2 in the left eye), each combination was considered to yield 9 potential subject level outcomes for 2 analyses.
Subject Research Methods; Index Variables; Statistical Considerations
OCR Text Show
Date 2021-12
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, December 2021, Volume 41, Issue 4
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6hc48vm
Setname ehsl_novel_jno
ID 2116176
Reference URL https://collections.lib.utah.edu/ark:/87278/s6hc48vm
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