| Identifier |
20220213_nanos_posters_246 |
| Title |
Single Retinal Ganglion Cell Transcriptomics in a Model of Dominant Optic Atrophy |
| Creator |
Michael James Gilhooley; Nicholas Owen; Mariya Moosajee; Patrick Yu-Wai-Man |
| Affiliation |
(MJG) Moorfields Eye Hospital & The Institute of Ophthalmology, London, United Kingdom of Great Britain and Northern Ireland; (NO) (MM) (PYWM) The Institute of Ophthalmology, University College London, London, United Kingdom of Great Britain and Northern Ireland |
| Subject |
Optic Neuropathy; Optic Nerve Trauma and Treatment, Genetic Disease; Pupil; Neuro-ophthalmology & Systemic Disease (eg. MS, MG, Thyroid) |
| Description |
Melanopsin expressing Intrinsically-photosensitive-Retinal-Ganglion-Cells (ipRGCs) survive late in dominant optic atrophy (DOA), long after other RGC sub-types (and vision) have been lost. We hypothesise that specific neuroprotective genes, or pathways, are upregulated in ipRGCs transcriptomes compared to other RGC subtypes, affording them this resistance. These genes could, therefore, be harnessed to develop novel therapeutic strategies. Purpose (i)To evaluate a pathway for the preparation and enrichment of single cell suspensions of RGCs from mouse retina. (ii)To compare gene expression between RGC subpopulations (including ipRGCs) in a model of DOA using single cell RNA sequencing (scRNAseq). |
| Date |
2022-02 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2022 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2022: Poster Session I: Disorders of the Anterior Visual Pathway (Retina, Optic Nerve, and Chiasm) |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2022. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s63cep1x |
| Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
| Setname |
ehsl_novel_nam |
| ID |
2065064 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s63cep1x |
