Neurosarcoidosis and MOG-associated Disease

Myelin oligodendrocyte glycoprotein (MOG) is a protein found on the surface of myelin, and anti-MOG antibodies can be elevated in demyelinating conditions such as multiple sclerosis, neuromyelitis optica spectrum disorder, or other MOG- associated disease (MOGAD). In particular, MOGAD commonly presents with steroid-dependent bilateral optic neuritis. Neurosarcoidosis, an immune-mediated, noncaseating granulomatous disease, can also manifest with optic neuritis. Here, we present a unique patient with concurrent neurosarcoidosis and MOGAD.