The quantitative study of changes in anatomy

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Publication Type dissertation
School or College College of Engineering
Department Bioengineering
Author Hinkle, Jacob
Title The quantitative study of changes in anatomy
Date 2015-12
Description The statistical study of anatomy is one of the primary focuses of medical image analysis. It is well-established that the appropriate mathematical settings for such analyses are Riemannian manifolds and Lie group actions. Statistically defined atlases, in which a mean anatomical image is computed from a collection of static three-dimensional (3D) scans, have become commonplace. Within the past few decades, these efforts, which constitute the field of computational anatomy, have seen great success in enabling quantitative analysis. However, most of the analysis within computational anatomy has focused on collections of static images in population studies. The recent emergence of large-scale longitudinal imaging studies and four-dimensional (4D) imaging technology presents new opportunities for studying dynamic anatomical processes such as motion, growth, and degeneration. In order to make use of this new data, it is imperative that computational anatomy be extended with methods for the statistical analysis of longitudinal and dynamic medical imaging. In this dissertation, the deformable template framework is used for the development of 4D statistical shape analysis, with applications in motion analysis for individualized medicine and the study of growth and disease progression. A new method for estimating organ motion directly from raw imaging data is introduced and tested extensively. Polynomial regression, the staple of curve regression in Euclidean spaces, is extended to the setting of Riemannian manifolds. This polynomial regression framework enables rigorous statistical analysis of longitudinal imaging data. Finally, a new diffeomorphic model of irrotational shape change is presented. This new model presents striking practical advantages over standard diffeomorphic methods, while the study of this new space promises to illuminate aspects of the structure of the diffeomorphism group.
Type Text
Publisher University of Utah
Dissertation Institution University of Utah
Dissertation Name Doctor of Philosophy
Language eng
Rights Management Copyright © Jacob Hinkle 2015
Format Medium application/pdf
Format Extent 27,368 bytes
Identifier etd3/id/4044
ARK ark:/87278/s6kd567f
Setname ir_etd
Date Created 2016-08-03
Date Modified 2021-05-06
ID 197594
Reference URL
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