Adhesive complex coacervate inspired by the sandcastle worm as a sealant for fetoscopic defects

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Publication Type dissertation
School or College College of Engineering
Department Materials Science & Engineering
Author Kaur, Sarbjit
Title Adhesive complex coacervate inspired by the sandcastle worm as a sealant for fetoscopic defects
Date 2015-05
Description Inspired by the Sandcastle Worm, biomimetic of the water-borne adhesive was developed by complex coacervation of the synthetic copolyelectrolytes, mimicking the chemistries of the worm glue. The developed underwater adhesive was designed for sealing fetal membranes after fetoscopic surgery in twin-to-twin transfusion syndrome (TTTS) and sealing neural tissue of a fetus in aminiotic sac for spina bifida condition. Complex coacervate with increased bond strength was created by entrapping polyethylene glycol diacrylate (PEG-dA) monomer within the cross-linked coacervate network. Maximum shear bond strength of ~ 1.2 MPa on aluminum substrates was reached. The monomer-filled coacervate had complex flow behavior, thickening at low shear rates and then thinning suddenly with a 16-fold drop in viscosity at shear rates near 6 s-1. The microscale structure of the complex coacervates resembled a three-dimensional porous network of interconnected tubules. This complex coacervate adhesive was used in vitro studies to mimic the uterine wall-fetal membrane interface using a water column with one end and sealed with human fetal membranes and poultry breast, and a defect was created with an 11 French trocar. The coacervate adhesive in conjunction with the multiphase adhesive was used to seal the defect. The sealant withstood an additional traction of 12 g for 30-60 minutes and turbulence of the water column without leakage of fluid or slippage. The adhesive is nontoxic when in direct contact with human fetal membranes in an organ culture setting.
Type Text
Publisher University of Utah
Subject Adhesive; Biomimetic; Complex coacervate; Fetoscopic defects; Sandcastle worm; Soft tissue adhesive
Dissertation Name Doctor of Philosophy
Language eng
Rights Management Copyright © Sarbjit Kaur 2015
Format Medium application/pdf
Format Extent 2,156,058 bytes
Identifier etd3/id/3541
ARK ark:/87278/s61291zw
Setname ir_etd
Date Created 2015-06-09
Date Modified 2017-09-21
ID 197094
Reference URL https://collections.lib.utah.edu/ark:/87278/s61291zw