A phase 1 double-blind comparison of the safety and tolerance of eight percent arildone (win 30820) to the ninety percent DMSO/ten percent PEG-400 vehicle during and following seven day topical application to immunocompromised patients

Diseases associated with some of the human herpes viruses have been recognized for centuries; these include fever blisters or herpes labialis, herpes genitalis, varicella and zoster. It is only within the past decade or two that the impact of these viruses in medicine has been appreciated. this increased interest has led to new information on various aspects of human herpes viruses and their resultant diseases, such as molecular and genetic basis, epidemiology, latency and oncogenesis, immunology, clinical spectrum, diagnosis, prevention and treatment, that is of critical interest to many many practitioners, since herpes simplex virus infections of the oral and genital areas are among the most common infectious illnesses involving human beings. Both Primary and recurrent forms of these vital infections occur. There is currently no consistently efficacious therapy for herpes infections. Although many different modalities have been tried, including antiviral agents such as adenine arabinoside and idoxuridine, topical surfactants including diethyl ether and chloroform, immunostimulators such as vaccines and photodynamic inactivation, none have met with great success.