The axon guidance molecule netrin is required in the quidance of dendrites and vascular endothelial gells.

Update item information
Publication Type dissertation
School or College School of Medicine
Department Neurobiology & Anatomy
Author Suli, Arminda.
Title The axon guidance molecule netrin is required in the quidance of dendrites and vascular endothelial gells.
Date 2007-08
Description The biological question that interests me is: How do we make functional nervous and vascular systems? One of the first steps in this process is guiding neurons with their axons and dendrites, and vascular endothelial cells, toward the right places at the right times. To address the question of guidance, I have looked at Netrin, a guidance molecule known to be important in axonal guidance, and its role in guiding dendrites and vascular endothelial cells in vivo during zebrafish embryonic development. The dendritic guidance work has been done in the octavolateralis efferent system, which gives efferent input to the lateral line and ear and has pronounced dendrites that cross the midline. For the vascular work, I have concentrated on the development of the trunk vasculature and particularly on the formation of the parachordal vessel, a venous vessel that extends along the horizontal myoseptum and interconnects venous intersegmental vessels. Chapter 1 is an introductory chapter in which I present the major questions I am trying to answer and the appropriate background on guidance, the octavolateralis efferent system, the vascular system, and Netrin signaling. Chapter 2 is a peer-reviewed paper published in "The Journal of Neuroscience" in which I show that Netrin is important for the contralateral dendrites of the octavolateralis efferent neurons as they extend toward the midline. Chapter 3 is a collaborative peer-reviewed paper published in the journal Science giving evidence that Netrin promotes angiogenesis, or sprouting of blood vessels from preexisting vessels, in vivo and in vitro. I contributed all of the zebrafish results. Chapter 4 is written in the format of a peer-reviewed paper and shows the latest work I have done in finding the mechanism by which Netrin promotes parachordal vessel (PAV) formation. Finally, Chapter 5 (Conclusions) discusses the findings of this work and future directions.
Type Text
Publisher University of Utah
Subject Nervous System; Neurogenetics; Cardiovascular System
Subject MESH Dendrites; Neurons; Axons
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "The axon guidance molecule netrin is required in the quidance of dendrites and vascular endothelial gells." Spencer S. Eccles Health Sciences Library. Print version of "The axon guidance molecule netrin is required in the quidance of dendrites and vascular endothelial gells." available at J. Willard Marriott Library Special Collection. QP6.5 2007 .S94.
Rights Management © Arminda Suli.
Format Medium application/pdf
Identifier us-etd2,221
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
ARK ark:/87278/s6902jfh
Setname ir_etd
Date Created 2012-04-23
Date Modified 2012-04-23
ID 193915
Reference URL https://collections.lib.utah.edu/ark:/87278/s6902jfh