Role of hoxa1 in mammalian hindbrain, inner ear and neural crest development

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Publication Type dissertation
School or College School of Medicine
Department Human Genetics
Author Makki, Nadja
Title Role of hoxa1 in mammalian hindbrain, inner ear and neural crest development
Date 2010
Description Homeobox transcription factors belong to a family of proteins involved in an array of developmental processes, the most important being specification of the anteriorposterior axis of the embryo. The first and one of the most anteriorly expressed Hox genes during development is Hoxa1. Mouse knockout studies have revealed that loss of Hoxa1 function leads to mispatterning of the hindbrain, in addition to defects in the inner ear, cranial ganglia, and the breathing inducing cells in rhombomere 3. More recently, humans with homozygous mutations in Hoxa1 have been identified, which sparked new interest in understanding the role this crucial transcription factor plays during development. Interestingly, human patients in addition to the defects described in mice, also display cardiovascular abnormalities.
Type Text
Publisher University of Utah
Subject Hoxa1; Mammalian; Hindbrain; Inner ear; Neural crest; Development; Rhombencephalon; Homeobox transcription factors; Hox genes
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Rights Management ©Nadja Makki
Format Medium application/pdf
Format Extent 17,740,986 bytes
Source Original housed in Marriott Library Special Collections, QH9.7 2010 .M34
ARK ark:/87278/s68k7qqm
Setname ir_etd
Date Created 2012-04-23
Date Modified 2021-05-06
ID 193799
Reference URL
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