A new standard method for determination of oxygen content.

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Publication Type dissertation
School or College School of Medicine
Department Biomedical Informatics
Author Yen, Ming-Cheng.
Title A new standard method for determination of oxygen content.
Date 1982-03
Description A modified polarographic method for measuring oxygen content in whole blood, which has first principle measurement status equal to that of the Van Slyke manometric method, is described. First principle measurement status is achieved by an oxygen sensor nulling technique which eliminates the influence of the characteristics of the sensor from the oxygen measurement. The method is also characterized by a simplifying continuous flow proportioning feature which improves the accuracy and reliability of the method by eliminating the requirement of blood and diluent volume metering by the operator. This feature also provides the basis for automatic quality checks of the blood sample; microbubbles or non-uniform red blood cell concentrations, which could indicate that the blood sample is not representative of its source, are readily detected by a variance analysis of the data. The results of a paired sample study showed no statistical difference between this and the Van Slyke methods (mean difference = 0.005 V% and SD = 0.35 V%). The advantages of this method over the Van Slyke are mainly those provided by the design simplicity which lends itself to microprocessor control. Those advantages include: (1) operator independent accuracy and precision, (2) reduced measurement time (4.5 minutes), and (3) small sample size (0.4 ml which can be reduced much further).
Type Text
Publisher University of Utah
Subject Spectrophotometry; Histogram
Subject MESH Oxygen; Blood
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "A new standard method for determination of oxygen content." Spencer S. Eccles Health Sciences Library. Print version of "A new standard method for determination of oxygen content." available at J. Willard Marriott Library Special Collection. QP 6.5 1982 Y45.
Rights Management © Ming-Cheng Yen.
Format Medium application/pdf
Identifier us-etd2,10
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
ARK ark:/87278/s6g16ffp
Setname ir_etd
Date Created 2012-04-23
Date Modified 2021-05-06
ID 193635
Reference URL https://collections.lib.utah.edu/ark:/87278/s6g16ffp
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