Effects of a single dose of Quercetin on cardiovascular function in normotensive and hypertensive men

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Publication Type dissertation
School or College College of Health
Department Exercise & Sport Science
Author Larson, Abigail J
Title Effects of a single dose of Quercetin on cardiovascular function in normotensive and hypertensive men
Date 2010-08
Description Quercetin is a flavonoid found in apples, berries, and onions. Epidemiological studies have found an inverse relationship between quercetin intake and risk of cardiovascular disease and stroke. Quercetin supplementation has been found to reduce severity of hypertension (HTN), improve endothelial and vascular smooth muscle function, and decrease angiotensin converting enzyme (ACE) activity in vivo and in vitro in animal models. Recently, quercetin's ability to protect against cardiovascular disease in humans has been studied. Evidence suggests that quercetin reduces blood pressure (BP) in hypertensive humans; however, the mechanisms for this phenomenon remain unclear. Furthermore, previous studies have used quercetin supplementation over a period >28 days and it is unclear if quercetin reduces BP acutely or if long-term supplementation is required. The purpose of my research was to determine the effects of a single 1095 mg quercetin aglycone supplement on BP, heart rate (HR), and ACE activity, in normotensive (n = 5) and hypertensive (n = 12) men. Markers of endothelial function (flow mediated dilation (FMD) and concentrations of endothelin-1 (ET-1) and nitric oxide (NO) metabolites) were also measured in the hypertensive participants. A secondary purpose was to determine bioavailability and the metabolism rate of a single 1095 mg dose of quercetin. This was the first study to examine the effects of a single quercetin dose on cardiovascular and endothelial function in hypertensive individuals. We found10 hours post ingestion of quercetin SBP, DBP, and MAP (mm Hg)
Type Text
Publisher University of Utah
Subject ACE activity; Endothelial function; flow mediated dilation; Hypertension; Quercetin
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Rights Management ©Abigail J. Larson
Format Medium application/pdf
Format Extent 6,281 bytes
Identifier us-etd2,159585
ARK ark:/87278/s654336h
Setname ir_etd
Date Created 2012-04-23
Date Modified 2017-10-11
ID 193560
Reference URL https://collections.lib.utah.edu/ark:/87278/s654336h