Investigating the Cellular Basis of Excessive Grooming Behavior in HoxB8 Mutant Mice

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Publication Type dissertation
School or College School of Medicine
Department Human Genetics
Author Chen, Shau-Kwaun
Title Investigating the Cellular Basis of Excessive Grooming Behavior in HoxB8 Mutant Mice
Date 2010-04-19
Description Excessive grooming behavior has been reported in Hoxb8 loss-of-function mutants. Since Hoxb8 expresses in various tissues in mice, the cause of the excessive grooming and hair removal phenotype was not clear. In this report we demonstrated that Hoxb8 is expressed in brain microglia hematopoietic systems. Immunological aberration in the function of hematopoietic system has been long considered as potential etiology for psychiatric disorders. Therefore bone marrow transplantation and conditional mutagenesis were conducted in our analysis to determine if malfunctioned hematopoietic system is associated with excessive grooming phenotype. Excessive grooming phenotype is rescued in hematopoietic chimeric Hoxb8 mutant mice carrying bone marrow cells derived from wildtype mice. On the other hand, nociception insensitivity remains evident in those phenotype rescued hematopoietic chimeras. Conditionally inactivation of Hoxb8 gene in hematopoietic systems recapitulated the hair removal and excessive grooming phenotype, but did not recapitulate dorsal spinal cord and sensory defects. These observations indicated that the sensory defects could be genetically separated from is not the primary cause the excessive grooming phenotype associated with the Hoxb8 disruption. Further, the histological test in skin shows no aberrant immune cell infiltration in the infected tissue. These observations support the conclusion that the hair loss and excessive grooming phenotype in Hoxb8 mutant mice is primary associated with the function of Hoxb8 in hematopoietic systems. This is also the first model systems to directly support the long existing hypothesis that dysfunctions of the hematopoietic system and immunological alterations can be lead to the etiology of behavioral disorders, such as obsessive compulsive disorder, major depression and schizophrenia.
Type Text
Publisher University of Utah
Subject Grooming Behavior in Animals; Mice; Genetics
Subject MESH Grooming; Behavior, Animal; Hoxb8 protein, mouse; Mice, Neurologic Mutants
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "Investigating the cellular basis of excessive grooming in hoxb8 mutant mice." Spencer S. Health Sciences Library. Print version of "Investigating the cellular basis of excessive grooming behavior in hoxb8 mutant mice." available at J. Willard Marriott Library Special Collection. QL3.5 2009.C44.
Rights Management © Shau-Kwaun Chen
Format Medium application/pdf
Format Extent 1,591,024 bytes
Source Original: University of Utah Spencer S. Eccles Health Sciences Library
Conversion Specifications Original scanned on Fujitsi fi-5220G as 400 dpi to pdf using ABBYY FineReader 10
ARK ark:/87278/s6kk9sdz
Setname ir_etd
Date Created 2012-04-23
Date Modified 2021-05-06
ID 193488
Reference URL https://collections.lib.utah.edu/ark:/87278/s6kk9sdz
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