Preopertive and postoperative levels of diphosphoglycerate following elective surgery under general anesthesia.

Update item information
Publication Type thesis
School or College College of Nursing
Department Nursing
Author Abdulla, Judith Jensen.
Title Preopertive and postoperative levels of diphosphoglycerate following elective surgery under general anesthesia.
Date 1979-12
Description Diphosphoglycerate (DPG) plays an integral part in the transport of oxygen to tissues. By binding reversibly with hemoglobin, DPG decreases hemoglobin's affinity for oxygen and increases oxygen availability to the tissues. Multiple factors affect the synthesis and binding ability of DPG and indirectly alter oxygen availability to the tissues. General aesthesia imposes many physiologic alterations which, when considered individually, are known to alter DPG levels. The purpose of the present study was to quantify, describe, and compare the preoperative and postoperative measurements of DPG levels in non-acute patients undergoing anesthesia. DPG levels on 30 healthy adults (19 females and 11 males) were obtained before and after elective surgery under general anesthesia. DPG levels decreased from a preoperative mean of 2.34 um-mols/ml to a postoperative mean of 1.83 um-mols/ml (p<.001). This decrease was unrelated to type of anesthetic agent, length of anesthesia, or estimated blood loss. Although actual decreases in tissues oxygenation postoperatively were not measured, some decrease may occur as a result of the decrease in DPG levels. Therefore, nursing measures which promote optimal tissue oxygenation should be directed toward every postoperative patient.
Type Text
Publisher University of Utah
Subject Adverse Effects; Metabolism
Subject MESH Anesthesia; Oxygen; Biological Transport
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Preopertive and postoperative levels of diphosphoglycerate following elective surgery under general anesthesia." Spencer S. Eccles Health Sciences Library. Print version of "Preopertive and postoperative levels of diphosphoglycerate following elective surgery under general anesthesia." available at J. Willard Marriott Library Special Collection. RD 14.5 1979 A23.
Rights Management © Judith Jensen Abdulla.
Format Medium application/pdf
Identifier us-etd2,141
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
ARK ark:/87278/s6t72xwz
Setname ir_etd
Date Created 2012-04-23
Date Modified 2012-04-23
ID 192303
Reference URL https://collections.lib.utah.edu/ark:/87278/s6t72xwz