Serum opsonic activity in splenectomized Hodgkin's disease patients.

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Publication Type thesis
School or College School of Medicine
Department Biomedical Informatics
Author Sears, Tena Susanne.
Title Serum opsonic activity in splenectomized Hodgkin's disease patients.
Date 1978-08
Description Overwhelming infection represents a significant hazard in patients following splenectomy or in functional asplenia due to a variety of disorders. Defects in the alternative complement pathway (ACP) activity have been suggested in several of these disorders. In the present study, nonspecific opsonic activiaty in Hodgkin's disease patients was investigated at various intervals post-splenectomy. A few patients were evaluated prior to surgery. This activity was measured indirectly by PMN chemiluminescence (CL) produced as the leukocytes phagocytize opsonized sera from patients and controls. ACP opsonic activity as measured by the CL produced was slightly depressed 10-31 days postoperatively but usually returned to normal levels one month after surgery in adults. In three adolescent patients, decreased opsonic activity persisted. No such depression was evident in non-chelated sera. Factor B and IgM levels did not correlate with the depressed activity. These data suggest that nonspecific opsonic activity of the ACP is transiently decreased in Hodgkin's disease patients following splenectomy; and, component(s) other than Factor B and IgM may be responsible for this abnormality. Additional investigations are indicated, however, to confirm these trends and correlate them with the propensity to develop overwhelming post-splenectomy infections.
Type Text
Publisher University of Utah
Subject Kinetics; Phagocyte
Subject MESH Opsonins; Hodgkin Disease
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Serum opsonic activity in splenectomized Hodgkin's disease patients." Spencer S. Eccles Health Sciences Library. Print version of "Serum opsonic activity in splenectomized Hodgkin's disease patients." available at J. Willard Marriott Library Special Collection. RC 39.5 1978 S43.
Rights Management © Tena Susanne Sears.
Format Medium application/pdf
Identifier us-etd2,53
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
ARK ark:/87278/s65t40xz
Setname ir_etd
Date Created 2012-04-23
Date Modified 2012-04-23
ID 192246
Reference URL