Total parenteral nutrition alters hepatic drug conjugation in rats

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Publication Type dissertation
School or College College of Pharmacy
Department Pharmaceutics & Pharmaceutical Chemistry
Author Raftogianis, Rebecca Blanchard
Title Total parenteral nutrition alters hepatic drug conjugation in rats
Date 1995-03
Description Total parenteral nutrition (TPN) provides complete nutritional support in settings in which patients cannot eat. TPN, typically administered through a central vein as an elemental nutrient solution, bypasses the intestinal tract and causes adverse effects to the gut and liver. TPN has also been shown to depress hepatic drug oxidation, but its effects on drug conjugation have not been characterized. The purpose of this research was to examine the effects of TPN on hepatic drug conjugation in male Sprague Dawley rats and to investigate the role of such factors as the composition of TPN solutions and the route of administration in contributing to alterations in hepatic drug metabolism. Results confirm that TPN depresses hepatic drug oxidation and further indicate that TPN diminishes the in vitro rate of hepatic conjugation reactions and decreases the total clearance of acetaminophen in vivo due to decreased formation of the sulfate metabolite. These changes occur independently of parenteral route of administration (portal vein vs. inferior vena cava) and may linger for greater than one week after normal feeding has been resumed. Substituting 25% of the nonprotein calories with lipid similarly alters drug metabolism. When the TPN solution is administered enterally, however, hepatic drug metabolism is unaffected compared to chow fed animals. These investigations suggest that intestinal physiology is an important regulator of hepatic drug metabolism.
Type Text
Publisher University of Utah
Subject Prostaglandin; Glutathione
Subject MESH Parenteral Nutrition, Total; Pharmaceutical Preparations; Liver
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "Total parenteral nutrition alters hepatic drug conjugation in rats." Spencer S. Eccles Health Sciences Library. Print version of "Total parenteral nutrition alters hepatic drug conjugation in rats." available at J. Willard Marriott Library Special Collection. RM31.5 1995 .R34.
Rights Management © Rebecca Blanchard Raftogianis.
Format Medium application/pdf
Format Extent 2,377,540 bytes
Identifier undthes,5355
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Funding/Fellowship Predoctoral fellowship from the American Foundation for Pharmaceutical Education.
Master File Extent 2,377,604 bytes
ARK ark:/87278/s6hh6n0g
Setname ir_etd
Date Created 2012-04-24
Date Modified 2012-04-24
ID 191911
Reference URL