Genetic effects of occupational exposure to styrene as measured using the micronucleus test

Update item information
Publication Type thesis
School or College School of Medicine
Department Family & Preventive Medicine
Author Blumer, Michael Kevin
Title Genetic effects of occupational exposure to styrene as measured using the micronucleus test
Date 1986-12
Description Styrene has been shown to be mutagenic upon metabolic activation. However, studies of occupationally exposed populations have shown conflicting results when looking for chromosomal effects. The present study was conducted to help determine the chromosomal effects of occupational exposure to styrene. Lymphocyte micronuclei were used as indicators of chromosomal breakage. Eight exposed subjects involved in fiberglass fabrication and six matched controls from a metal fabrication company were studied. Styrene exposure was measured using an infrared analyzer and passive organic vapor monitors. Actual styrene dosage and metabolism was documented with end-of-shift urinary mandelic acid measurements. Lifetime styrene exposure was calculated from questionnaire data. Micronuclei were counted in lymphocytes with intact cytoplasm. The exposed subjects showed an increase in lymphocyte micronuclei, but the increase was not statistically significant. No dose response relationship was found between current styrene exposure and micronucleus levels, mandelic acid and micronucleus levels, or lifetime styrene exposure and micronucleus levels.
Type Text
Publisher University of Utah
Subject Adverse Effects; Fiberglass Fabrication
Subject MESH Styrenes; Environmental Exposure; Genetics; Mutagenesis
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "The Genetic effects of occupational exposure to styrene as measured using the micronucleus test.© Spencer S. Eccles Health Sciences Library. Print version of "The Genetic effects of occupational exposure to styrene as measured using the micronucleus test". available at J. Willard Marriott Library Special Collection. RA 4.5 1986 B58.
Rights Management © Michael Kevin Blumer.
Format Medium application/pdf
Format Extent 1,608,706 bytes
Identifier undthes,4448
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Master File Extent 1,608,762 bytes
ARK ark:/87278/s6w95bxt
Setname ir_etd
Date Created 2012-04-24
Date Modified 2012-04-24
ID 190630
Reference URL https://collections.lib.utah.edu/ark:/87278/s6w95bxt