The anatomic pathway involved in horizontal saccadic eye movements include the frontal eye fields, paramedian pontine reticular formation (PPRF), medial longitudinal fasciculus (MLF), and cranial nerve nuclei III and VI. The pathway for the vestibulo- ocular reflex (VOR) passes through the PPRF at the level of the abducens nuclei. Lesions of the PPRF at that level disrupt the VOR, whereas lesions of the PPRF more rostrally in the upper pons, are associated with the ipsilateral saccadic palsy, but with a normal VOR.
Robert B. Daroff, MD, Professor of Neurology, School of Medicine, CASE Western Reserve University, University Hospitals - Case Medical Center
Spencer S. Eccles Health Sciences Library, University of Utah