Identifier |
wh_ch37_p1766 |
Title |
Walsh & Hoyt: Alkylating Agents |
Creator |
Mark L. Moster, MD; Rod Foroozan, MD |
Affiliation |
(MLM) Thomas Jefferson University; (RF) Baylor College of Medicine |
Subject |
Neoplasms; Neoplasms, Therapy; Chemotherapy, Adverse Effects; Radiotherapy, Adverse Effects; Bone Marrow Transplantation, Adverse Effects; Alkylating Agents; Complications of Cancers; Neuro-ophthalmic Complications of Chemotherapy |
Description |
Alkylating agents cause linking of nucleic acids, resulting in cross-linking between DNA strands, between bases in the same DNA strand or within a monoalkylated DNA guanine unit. Although these agents are cell cycle phase nonspecific, the biologic consequences are more severe when alkylation occurs during DNA synthesis. Alkylating agents may also cause apoptosis in sensitive cells. Alkylating agents are teratogenic, mutagenic, and carcinogenic, the most common secondary malignancy being acute leukemia. Nitrogen mustards. Mechlorethamine. Chlorambucil, Cyclophosphamide. Ifosfamide. Procarbazine. Dacarbazine. Chlorambucil. Busulfan (Myleran). Cytoxan. Nitrosoureas. BCNU (carmustine). CCNU (lomustine). Methyl-CCNU (semustine). PCNU. Streptozotocin. Chlorozotocin. HeCNU. ACNU (nimustine). Cisplatin (cis-diamminedichloroplatinum). Carboplatin. Oxaliplatin. Thiotepa. Temozolamide. Altretamine (hexamethylmelamine). |
Date |
2005 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
Walsh and Hoyt's Clinical Neuro-Ophthalmology, 6th Edition |
Relation is Part of |
Walsh and Hoyt's Clinical Neuro-Ophthalmology Walsh and Hoyt's Clinical Neuro-Ophthalmology |
Collection |
Neuro-Ophthalmology Virtual Education Library: Walsh and Hoyt Textbook Selections Collection: https://NOVEL.utah.edu |
Publisher |
Wolters Kluwer Health, Philadelphia |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
Copyright 2005. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s68s7zf0 |
Setname |
ehsl_novel_whts |
ID |
186353 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s68s7zf0 |