Identifier |
20160229_nanos_hottopics1_04 |
Title |
NMO: What You Need to Know (.pdf) |
Creator |
Sashank Prasad |
Affiliation |
Harvard Medical School, Brigham and Women's Hospital, Boston, MA |
Subject |
Neuromyelitis Optica Spectrum Disorder; Optic Neuritis; Myelitis; Anti-aquaporin-4 Antibodies |
Description |
Neuromyelitis optica (NMO) is an antibody-mediated inflammatory disease of the central nervous system with a predilection for the optic nerves, spinal cord, and certain brain regions.1 While NMO was previously considered to be a variant of multiple sclerosis (MS), it is now known to have distinct clinical, pathological and immunological features. The identification of NMO-IgG, a pathogenic antibody against aquaporin-4 (AQP4), delineated NMO from MS.Early, accurate diagnosis of NMO permits treatment with appropriate acute and long-term immunosuppressive agents that are critical to mitigate the risk of disability associated with this disease. The distinct pathogenesis of NMO relates to aquaporin-4 autoimmunity and complement-mediated tissue injury. Better understanding of this pathophysiology has laid the foundation for targeted efforts to develop novel, disease-specific treatments. In this review, we discuss the revised diagnostic criteria for NMO, review evidence supporting the use of available treatments for acute episodes and long-term disease modification, and highlight key emerging immunotherapies. |
Date |
2016-02-29 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2016 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2016: Hot Topics - Today and Tomorrow |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
ARK |
ark:/87278/s6351s8n |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
185338 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6351s8n |