NMO: What You Need to Know (.pdf)

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Identifier 20160229_nanos_hottopics1_04
Title NMO: What You Need to Know (.pdf)
Creator Sashank Prasad, MD, Brigham and Women's Hospital
Subject Neuromyelitis Optica Spectrum Disorder, Optic Neuritis, Myelitis, Anti-aquaporin-4 Antibodies
Description "Neuromyelitis optica (NMO) is an antibody-mediated inflammatory disease of the central nervous system with a predilection for the optic nerves, spinal cord, and certain brain regions.1 While NMO was previously considered to be a variant of multiple sclerosis (MS), it is now known to have distinct clinical, pathological and immunological features. The identification of NMO-IgG, a pathogenic antibody against aquaporin-4 (AQP4), delineated NMO from MS.Early, accurate diagnosis of NMO permits treatment with appropriate acute and long-term immunosuppressive agents that are critical to mitigate the risk of disability associated with this disease. The distinct pathogenesis of NMO relates to aquaporin-4 autoimmunity and complement-mediated tissue injury. Better understanding of this pathophysiology has laid the foundation for targeted efforts to develop novel, disease-specific treatments. In this review, we discuss the revised diagnostic criteria for NMO, review evidence supporting the use of available treatments for acute episodes and long-term disease modification, and highlight key emerging immunotherapies."
Relation is Part of NANOS Annual Meeting 2016: Hot Topics - Today and Tomorrow
Contributor Primary Sashank Prasad, MD
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2016-02-29
Type Text
Format application/pdf
Format Creation application/pdf
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Language eng
ARK ark:/87278/s6351s8n
Setname ehsl_novel_nam
Date Created 2016-08-02
Date Modified 2017-05-04
ID 185338
Reference URL https://collections.lib.utah.edu/ark:/87278/s6351s8n
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