Long Term Follow Up of Children with Downgaze Nystagmus at Infancy (.pdf)

Paroxysmal downgaze nystagmus of infant is an unsettling phenomenon that leads to extensive work-up, although benign outcomes have been reported in sporadic cases. However, long term outcome of these children was not published. Our aim is to report a case series of 7 healthy infants with long neurological and ophthalmological follow up. They all presented with acute onset of episodic paroxysmal tonic downgaze at the ages of 2-12 weeks of age. We describe their spontaneous resolution without neurologic or ophthalmological sequelae.