Langerhan's Cell Histiocytosis Masquerading as Optic Glioma (.pdf)

"Langerhans cell histiocytosis (LCH) is a rare disease of uncertain etiology. LCH possibly related to clonal proliferation of CD1a-positive langerhans cells forming a pseudotumoral growth. LCH may present as unifocal, multifocal with a benign or fatal course. LCH disorders are classified into 3 groups: eosinophilic granuloma, Hand-Schüller-Christian disease and Letterer-Siwe disease. The incidence of LCH ranges from 1 to 9 cases per million/ year. Of all cases of LCH, temporal bone involvement has been reported in 20% to 30%. Herein we present an unusual case of LCH masquerading as optic glioma. The clinical, radiological and histopathological results are discussed. "