Safety and Tolerability of Acetazolamide

Identifier 20150225_nanos_hottopic2_04-1
Title Safety and Tolerability of Acetazolamide
Creator Martin ten Hove, MD, M.Eng, FRCS(C), Queen's University, Kingston, ON
Subject Idiopathic intracranial hypertension; Acetazolamide; IIHTT; Safety; Tolerability
Description Idiopathic intracranial hypertension (IIH) is a disease of unknown etiology that occurs primarily in young obese women with an estimated incidence of 0.9/100,00 in the general population1. The current medical treatment paradigm for IIH aims to decrease intracranial pressure (ICP) by decreasing the production of Cerebrospinal Fluid (CSF)2. Conventional medical management of IIH with carbonic anhydrase inhibitors (CAIs) such as acetazolamide was first suggested by Lubow and Kuhr3 . Clinically, resolution of optic disc edema has been demonstrated in IIH patients using acetazolamide at 1g/d4. In 1978, a case series of 4 IIH patients in which ICP was continuously monitored before and after treatment showed that in 2 of those cases, acetazolamide at 4g/d was effective in gradually reducing ICP5 however data pertaining to safety or tolerability was not reported. In this syllabus, we examine the safety and tolerability data from the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT), presenting evidence on the type, frequency, and relative risks of experiencing AEs in patients receiving acetazolamide up to 4g/d. A discussion of SAEs that occurred during the treatment phase of the trial is also presented.
Relation is Part of NANOS Annual Meeting 2015 Sizzling Hot Topic: The IIHTT: What Have We Learned?
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date 2015-02-25
Type Text
Format application/pdf
Format Creation application/pdf
Source 2015 North American Neuro-Ophthalmology Society Annual Meeting
Rights Management North American Neuro-Ophthalmology Association (NANOS), Copyright 2017. For further information regarding the rights to this collection, please visit http://library.med.utah.edu/NOVEL/about/copyright
Holding Institution North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416
Collection Neuro-Ophthalmology Virtual Education Library: NOVEL, NANOS Annual Meeting, https://novel.utah.edu/collection/NAM/index/
Language eng
ARK ark:/87278/s6b59rnc
Setname ehsl_novel_nam
Date Created 2015-12-10
Date Modified 2017-04-27
ID 185042
Reference URL https://collections.lib.utah.edu/details?id=185042
Back to Search Results